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    Fzr1 fizzy and cell division cycle 20 related 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314642, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzr1provided by RGD
    Official Full Name
    fizzy and cell division cycle 20 related 1provided by RGD
    Primary source
    RGD:1308713
    See related
    EnsemblRapid:ENSRNOG00000004169 AllianceGenome:RGD:1308713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdh1
    Summary
    Predicted to enable anaphase-promoting complex binding activity; ubiquitin ligase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; negative regulation of cell cycle process; and positive regulation of protein metabolic process. Predicted to act upstream of or within lens fiber cell differentiation; proteolysis involved in protein catabolic process; and regulation of meiotic nuclear division. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 118.8), Testes (RPKM 66.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fzr1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8982765..8994689)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8332029..8343953)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11201690..11213614)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 44 Neighboring gene deoxyhypusine hydroxylase Neighboring gene tektin bundle interacting protein 1 Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene high mobility group 20 B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding  
    enables protein binding PubMed 
    enables ubiquitin ligase activator activity  
    enables ubiquitin-like ligase-substrate adaptor activity  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    fizzy-related protein homolog
    Names
    fizzy/cell division cycle 20 related 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108074.2NP_001101544.2  fizzy-related protein homolog

      See identical proteins and their annotated locations for NP_001101544.2

      Status: PROVISIONAL

      Source sequence(s)
      BC162059
      UniProtKB/TrEMBL
      A0A8I5ZWS1, B1WCA1, F7EFQ4
      Related
      ENSRNOP00000005624.6, ENSRNOT00000005624.7
      Conserved Domains (2) summary
      cd00200
      Location:193471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:232269
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8982765..8994689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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