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    Naxd NAD(P)HX dehydratase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361185, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naxdprovided by RGD
    Official Full Name
    NAD(P)HX dehydrataseprovided by RGD
    Primary source
    RGD:1562691
    See related
    EnsemblRapid:ENSRNOG00000015021 AllianceGenome:RGD:1562691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Carkd; RGD1562691
    Summary
    Enables ATP-dependent NAD(P)H-hydrate dehydratase activity. Involved in metabolite repair. Predicted to be located in membrane and mitochondrion. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 184.4), Kidney (RPKM 127.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Naxd in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84689776..84706256, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77986148..78004200, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83326228..83342711, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inhibitor of growth family, member 1 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC134482536 Neighboring gene uncharacterized LOC102553902 Neighboring gene RAB20, member RAS oncogene family Neighboring gene collagen type IV alpha 2 chain

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in metabolite repair  
    involved_in metabolite repair PubMed 
    involved_in nicotinamide nucleotide metabolic process  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in membrane  
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Names
    ATP-dependent NAD(P)HX dehydratase
    carbohydrate kinase domain containing
    carbohydrate kinase domain-containing protein
    NP_001101872.1
    XP_006253527.1
    XP_008769625.1
    XP_017455678.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108402.1NP_001101872.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase

      See identical proteins and their annotated locations for NP_001101872.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/Swiss-Prot
      D4AAT7
      UniProtKB/TrEMBL
      A6IWP6
      Conserved Domains (1) summary
      cd01171
      Location:49316
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      84689776..84706256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253465.5XP_006253527.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1

      See identical proteins and their annotated locations for XP_006253527.1

      UniProtKB/TrEMBL
      A0A8I5ZNB5, A6IWP7, D3ZLK9
      Related
      ENSRNOP00000060397.2, ENSRNOT00000065043.5
      Conserved Domains (1) summary
      cd01171
      Location:87354
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
    2. XM_017600189.3XP_017455678.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X2

      UniProtKB/Swiss-Prot
      D4AAT7
    3. XM_008771403.4XP_008769625.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACT3
      Related
      ENSRNOP00000091976.1, ENSRNOT00000100855.2
      Conserved Domains (1) summary
      cd01171
      Location:49237
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
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