Icmt isoprenylcysteine carboxyl methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Icmtprovided by RGD
Official Full Name: isoprenylcysteine carboxyl methyltransferaseprovided by RGD
Primary source: RGD:621618
See related: EnsemblRapid:ENSRNOG00000010953 AllianceGenome:RGD:621618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: fcmt
Summary: Enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; S-adenosylhomocysteine metabolic process; and S-adenosylmethioninamine metabolic process. Predicted to be located in cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in endoplasmic reticulum. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 137.6), Kidney (RPKM 116.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (168084487..168097519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (162804368..162811129)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (169475270..169482031)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that ICMT regulates glucose-induced Rac1 activation, generation of reactive oxygen species and insulin secretion in pancreatic beta-cells
Title: Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells.
findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway.
Title: Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C-terminal protein methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within C-terminal protein methylation	ISO Inferred from Sequence Orthology more info
involved_in CAAX-box protein maturation	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylhomocysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in S-adenosylmethioninamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of large ribosomal subunit	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-S-isoprenylcysteine O-methyltransferase

Names: PPMT; farnesyl cysteine carboxyl methyltransferase; pcCMT; prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methlytransferase; prenylcysteine carboxyl methyltransferase

NP_579844.2

EC 2.1.1.100

XP_063143178.1

EC 2.1.1.100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133310.2 → NP_579844.2 protein-S-isoprenylcysteine O-methyltransferase

See identical proteins and their annotated locations for NP_579844.2

Status: VALIDATED

Source sequence(s)

BC083923, CB616023

UniProtKB/Swiss-Prot

G3V7G5, Q9WVM4

Conserved Domains (1) summary

pfam04140
Location:164 → 257

ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family