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    RT1-T24-3 RT1 class I, locus T24, gene 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 414788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RT1-T24-3provided by RGD
    Official Full Name
    RT1 class I, locus T24, gene 3provided by RGD
    Primary source
    RGD:1624211
    See related
    EnsemblRapid:ENSRNOG00000032596 AllianceGenome:RGD:1624211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 318.0), Lung (RPKM 316.4) and 9 other tissues See more
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    Genomic context

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    See RT1-T24-3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2723043..2752691)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2718210..2730604)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3226010..3257254)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483846 Neighboring gene RT1 class I, locus T24, gene 4 Neighboring gene class I gene fragment 2361 Neighboring gene uncharacterized LOC120098968 Neighboring gene ribosomal protein L41, pseudogene 1 Neighboring gene class I gene fragment 2331 Neighboring gene RT1 class I, locus T24, gene 2 Neighboring gene class I gene fragment 2310 Neighboring gene uncharacterized LOC134483847 Neighboring gene uncharacterized LOC134483848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    RT1 class I, locus T24, gene 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166403.1 → NP_001159875.1  RT1 class I, locus T24, gene 3

      See identical proteins and their annotated locations for NP_001159875.1

      Status: VALIDATED

      Source sequence(s)
      BX883048
      UniProtKB/TrEMBL
      A0A0G2K8A4, F7EZJ6
      Related
      ENSRNOP00000074530.2, ENSRNOT00000078454.4
      Conserved Domains (3) summary
      cd00096
      Location:209 → 217
      Ig; Ig strand A [structural motif]
      cl08246
      Location:19 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:206 → 300
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      2723043..2752691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279401.1 → XP_063135471.1  RT1 class I, locus T24, gene 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8A4, F7EZJ6

    2. XM_039098963.2 → XP_038954891.1  RT1 class I, locus T24, gene 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8A4, F7EZJ6
      Conserved Domains (3) summary
      cd00096
      Location:209 → 217
      Ig; Ig strand A [structural motif]
      cl08246
      Location:19 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:206 → 300
      Ig; Immunoglobulin domain

    3. XM_063279400.1 → XP_063135470.1  RT1 class I, locus T24, gene 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8A4, F7EZJ6

    4. XM_063279402.1 → XP_063135472.1  RT1 class I, locus T24, gene 3 isoform X2

      UniProtKB/TrEMBL
      M0R642

    5. XM_063279403.1 → XP_063135473.1  RT1 class I, locus T24, gene 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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