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    Gstk1 glutathione S-transferase kappa 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297029, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gstk1provided by RGD
    Official Full Name
    glutathione S-transferase kappa 1provided by RGD
    Primary source
    RGD:735188
    See related
    EnsemblRapid:ENSRNOG00000016484 AllianceGenome:RGD:735188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GST13-13; GSTkappa
    Summary
    Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be involved in epithelial cell differentiation and glutathione metabolic process. Located in mitochondrial matrix. Orthologous to human GSTK1 (glutathione S-transferase kappa 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 566.4), Kidney (RPKM 206.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Gstk1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72085532..72089934)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71118979..71123298)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (71621777..71626096)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene taste receptor, type 2, member 139 Neighboring gene taste receptor, type 2, member 144 Neighboring gene peroxiredoxin 1, pseudogene 1 Neighboring gene transmembrane protein 139

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione peroxidase activity  
    enables glutathione peroxidase activity  
    enables glutathione transferase activity  
    enables glutathione transferase activity  
    Component Evidence Code Pubs
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    is_active_in peroxisome  
    located_in peroxisome  

    General protein information

    Preferred Names
    glutathione S-transferase kappa 1
    Names
    GST 13-13
    GST class-kappa
    GSTK1-1
    glutathione S-transferase subunit 13
    glutathione S-transferase, mitochondrial
    rGSTK1
    NP_852036.1
    XP_063141836.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181371.2NP_852036.1  glutathione S-transferase kappa 1

      See identical proteins and their annotated locations for NP_852036.1

      Status: PROVISIONAL

      Source sequence(s)
      S83436
      UniProtKB/Swiss-Prot
      O09034, P24473
      UniProtKB/TrEMBL
      B6DYQ0
      Related
      ENSRNOP00000022275.2, ENSRNOT00000022275.6
      Conserved Domains (1) summary
      cd03021
      Location:6211
      DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      72085532..72089934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285766.1XP_063141836.1  glutathione S-transferase kappa 1 isoform X1

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