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    Vapa VAMP associated protein A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58857, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vapaprovided by RGD
    Official Full Name
    VAMP associated protein Aprovided by RGD
    Primary source
    RGD:61803
    See related
    EnsemblRapid:ENSRNOG00000014765 AllianceGenome:RGD:61803
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Involved in neuron projection development. Located in endoplasmic reticulum membrane and nuclear membrane. Orthologous to human VAPA (VAMP associated protein A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 523.8), Adrenal (RPKM 476.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Vapa in Genome Data Viewer
    Location:
    9q37
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (112624791..112654731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (105177904..105208400, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (113300831..113331872, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18, pseudogene 10 Neighboring gene uncharacterized LOC134480621 Neighboring gene thioredoxin domain containing 2 Neighboring gene RAB31, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FFAT motif binding  
    enables identical protein binding PubMed 
    enables microtubule binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding PubMed 
    enables protein-membrane adaptor activity  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding  
    involved_in ceramide transport  
    involved_in cholesterol transport  
    NOT involved_in endoplasmic reticulum organization  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum-plasma membrane tethering  
    involved_in negative regulation by host of viral genome replication  
    involved_in neuron projection development  
    involved_in neuron projection development PubMed 
    involved_in neuron projection development  
    involved_in phospholipid transport  
    involved_in positive regulation by host of viral genome replication  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    NOT involved_in protein folding in endoplasmic reticulum  
    involved_in protein localization to endoplasmic reticulum  
    involved_in protein localization to endoplasmic reticulum  
    involved_in sphingomyelin biosynthetic process  
    involved_in sterol transport  
    involved_in viral release from host cell  
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    NOT located_in endoplasmic reticulum exit site  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane PubMed 
    located_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in nuclear membrane PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in vesicle  

    General protein information

    Preferred Names
    vesicle-associated membrane protein-associated protein A
    Names
    33 kDa Vamp-associated protein
    VAMP (vesicle-associated membrane protein)-associated protein A
    VAMP-A
    VAP-33
    VAP-A
    vesicle-associated membrane protein, associated protein a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031631.2NP_113819.3  vesicle-associated membrane protein-associated protein A

      See identical proteins and their annotated locations for NP_113819.3

      Status: PROVISIONAL

      Source sequence(s)
      BC061875
      UniProtKB/Swiss-Prot
      Q6P723, Q9Z270
      UniProtKB/TrEMBL
      A0A0G2K8E6, A6JRB7
      Related
      ENSRNOP00000020681.3, ENSRNOT00000020681.8
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      112624791..112654731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084144.2XP_038940072.1  vesicle-associated membrane protein-associated protein A isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8E6
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain
    2. XM_008767384.2XP_008765606.1  vesicle-associated membrane protein-associated protein A isoform X1

      See identical proteins and their annotated locations for XP_008765606.1

      UniProtKB/TrEMBL
      A0A0G2K8E6, A0A8I5ZVH7, A6JRB8
      Related
      ENSRNOP00000083505.1, ENSRNOT00000113264.2
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain
    3. XM_039084145.2XP_038940073.1  vesicle-associated membrane protein-associated protein A isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8E6, A0A8I6GHY4
      Related
      ENSRNOP00000074577.3, ENSRNOT00000086340.3
      Conserved Domains (1) summary
      pfam00635
      Location:7100
      Motile_Sperm; MSP (Major sperm protein) domain
    4. XM_063267660.1XP_063123730.1  vesicle-associated membrane protein-associated protein A isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8E6
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