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    Baiap2 BAR/IMD domain containing adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117542, updated on 9-Dec-2024

    Summary

    Symbol
    Baiap2provided by RGD
    Full Name
    BAR/IMD domain containing adaptor protein 2provided by RGD
    Primary source
    RGD:619814
    See related
    EnsemblRapid:ENSRNOG00000004049 AllianceGenome:RGD:619814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Irsp53
    Summary
    Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to epidermal growth factor stimulus; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 147.4), Testes (RPKM 73.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Baiap2 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105721371..105788549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105223065..105290130)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109107326..109187458)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480917 Neighboring gene charged multivesicular body protein 6 Neighboring gene uncharacterized LOC102555825 Neighboring gene microRNA 3065 Neighboring gene apoptosis-associated tyrosine kinase Neighboring gene microRNA 338 Neighboring gene microRNA 3594 Neighboring gene centrosomal protein 131

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding PubMed 
    enables cytoskeletal anchor activity  
    enables identical protein binding  
    enables proline-rich region binding  
    enables proline-rich region binding  
    enables protein binding PubMed 
    enables scaffold protein binding PubMed 
    enables transcription coregulator binding PubMed 
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in actin crosslink formation  
    involved_in actin crosslink formation  
    involved_in actin crosslink formation  
    involved_in actin filament bundle assembly  
    acts_upstream_of_or_within actin filament bundle assembly  
    involved_in actin filament bundle assembly  
    involved_in actin filament bundle assembly  
    involved_in cellular response to L-glutamate PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    acts_upstream_of_or_within dendrite development  
    involved_in modulation of chemical synaptic transmission  
    involved_in neuron differentiation PubMed 
    involved_in plasma membrane organization  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of dendritic spine morphogenesis PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in protein localization to synapse PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton PubMed 
    involved_in regulation of postsynapse organization PubMed 
    involved_in regulation of postsynapse organization PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity  
    Items 1 - 25 of 28
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in cytoplasm  
    located_in cytoskeleton  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft PubMed 
    located_in dendritic spine PubMed 
    located_in dendritic spine cytoplasm PubMed 
    located_in excitatory synapse PubMed 
    located_in filopodium  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in lamellipodium PubMed 
    located_in membrane  
    located_in microtubule PubMed 
    located_in neuron projection  
    located_in neuron projection branch point PubMed 
    located_in neuron projection terminus PubMed 
    located_in neuronal cell body PubMed 
    is_active_in nucleoplasm  
    located_in plasma membrane  
    located_in postsynapse PubMed 
    is_active_in postsynaptic cytosol PubMed 
    is_active_in postsynaptic density PubMed 
    is_active_in postsynaptic density PubMed 
    is_active_in postsynaptic density, intracellular component PubMed 
    located_in presynapse PubMed 
    is_active_in presynaptic cytosol PubMed 
    located_in ruffle  
    located_in secretory granule PubMed 
    located_in synaptic membrane PubMed 
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    BAR/IMD domain-containing adapter protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2
    Names
    BAI-associated protein 2
    BAI1-associated protein 2
    brain-specific angiogenesis inhibitor 1-associated protein 2-like
    insulin receptor substrate 53
    insulin receptor substrate p53
    insulin receptor substrate protein of 53 kDa
    insulin receptor tyrosine kinase substrate protein p53

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057196.1NP_476544.1  BAR/IMD domain-containing adapter protein 2

      See identical proteins and their annotated locations for NP_476544.1

      Status: PROVISIONAL

      Source sequence(s)
      AY037934
      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA2, A6HLA3
      Related
      ENSRNOP00000060172.3, ENSRNOT00000068437.6
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105721371..105788549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247872.4XP_006247934.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA3
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:338396
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    2. XM_006247869.5XP_006247931.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006247931.1

      UniProtKB/Swiss-Prot
      Q6GMN2, Q923H3
      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA0, A6HLA3
      Related
      ENSRNOP00000005687.6, ENSRNOT00000005687.8
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    3. XM_006247871.4XP_006247933.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA3
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:338396
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    4. XM_006247870.4XP_006247932.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006247932.1

      UniProtKB/TrEMBL
      A0A8I6A2M9, A0A8I6GJY9, A6HLA1, A6HLA3
      Related
      ENSRNOP00000084785.1, ENSRNOT00000094446.2
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    5. XM_039085085.2XP_038941013.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA3
      Conserved Domains (2) summary
      cd11915
      Location:320378
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_063268340.1XP_063124410.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJY9, A6HLA3
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