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    Aldob aldolase, fructose-bisphosphate B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24190, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aldobprovided by RGD
    Official Full Name
    aldolase, fructose-bisphosphate Bprovided by RGD
    Primary source
    RGD:2090
    See related
    EnsemblRapid:ENSRNOG00000006807 AllianceGenome:RGD:2090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aldo2; LIV10
    Summary
    Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to insulin stimulus; response to fructose; and response to interleukin-6. Located in perinuclear region of cytoplasm; rough endoplasmic reticulum membrane; and smooth endoplasmic reticulum membrane. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 18877.2) and Liver (RPKM 14191.4) See more
    Orthologs
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    Genomic context

    See Aldob in Genome Data Viewer
    Location:
    5q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (68684541..68697582, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (63889045..63902086, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64805772..64818813, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L50 Neighboring gene zinc finger protein 189 Neighboring gene uncharacterized LOC134478967 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables ATPase binding  
    enables cytoskeletal protein binding  
    enables cytoskeletal protein binding  
    enables fructose binding  
    enables fructose binding  
    enables fructose-1-phosphate aldolase activity  
    enables fructose-1-phosphate aldolase activity  
    enables fructose-1-phosphate aldolase activity  
    enables fructose-1-phosphate aldolase activity  
    enables fructose-bisphosphate aldolase activity  
    enables fructose-bisphosphate aldolase activity PubMed 
    enables fructose-bisphosphate aldolase activity  
    enables fructose-bisphosphate aldolase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables phosphatidylcholine binding PubMed 
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in NADH oxidation  
    involved_in NADH oxidation  
    involved_in cellular response to insulin stimulus PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process  
    involved_in fructose 1,6-bisphosphate metabolic process  
    involved_in fructose 1,6-bisphosphate metabolic process  
    involved_in fructose catabolic process  
    involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  
    involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate  
    involved_in fructose metabolic process  
    involved_in gluconeogenesis  
    involved_in glycolytic process  
    involved_in glycolytic process  
    involved_in glycolytic process  
    involved_in glycolytic process  
    involved_in liver development PubMed 
    involved_in negative regulation of pentose-phosphate shunt  
    involved_in negative regulation of pentose-phosphate shunt  
    involved_in positive regulation of ATP-dependent activity  
    involved_in response to amino acid PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to carbohydrate PubMed 
    involved_in response to copper ion PubMed 
    involved_in response to fructose PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to interleukin-6 PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to starvation PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to zinc ion PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in microtubule organizing center  
    located_in perinuclear region of cytoplasm PubMed 
    located_in rough endoplasmic reticulum membrane PubMed 
    located_in smooth endoplasmic reticulum membrane PubMed 

    General protein information

    Preferred Names
    fructose-bisphosphate aldolase B
    Names
    Aldolase B, fructose-biphosphate
    aldolase B, fructose-bisphosphate
    liver-type aldolase
    NP_036628.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012496.2NP_036628.2  fructose-bisphosphate aldolase B

      See identical proteins and their annotated locations for NP_036628.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081697
      UniProtKB/Swiss-Prot
      P00884, P70706
      UniProtKB/TrEMBL
      A0A0G2K9U5, Q66HT1
      Related
      ENSRNOP00000075134.1, ENSRNOT00000086505.3
      Conserved Domains (1) summary
      pfam00274
      Location:15364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      68684541..68697582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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