Spag5 sperm associated antigen 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spag5provided by RGD
Official Full Name: sperm associated antigen 5provided by RGD
Primary source: RGD:620152
See related: EnsemblRapid:ENSRNOG00000011777 AllianceGenome:RGD:620152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Deepest
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including protein localization to centrosome; regulation of cell cycle process; and regulation of metaphase plate congression. Predicted to act upstream of or within establishment of spindle orientation. Predicted to be located in several cellular components, including cytoskeleton; kinetochore; and nuclear body. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 95.5), Spleen (RPKM 76.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63693300..63714813)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63198717..63216746)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65552780..65585773)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

astrin (spag5) is necessary for the establishment of normal size (cell number) and function of the testis and kidney in rats.
Title: The microtubule-associated protein astrin transgenesis rescues spermatogenesis and renal function in hypogonadic (hgn/hgn) rats.
Spag5 mutation may cause a reduction in mitotic activity and an increase in apoptosis of fetal Sertoli cells in hgn/hgn testes.
Title: Reduced mitotic activity and increased apoptosis of fetal sertoli cells in rat hypogonadic (hgn/hgn) testes.
Different localization of Spag5 in somatic versus male germ cells suggests the possibility of different function.
Title: Rat Spag5 associates in somatic cells with endoplasmic reticulum and microtubules but in spermatozoa with outer dense fibers.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of metaphase plate congression	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm-associated antigen 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044224.1 → NP_001037689.1 sperm-associated antigen 5

See identical proteins and their annotated locations for NP_001037689.1

Status: PROVISIONAL

Source sequence(s)

AB231661

UniProtKB/TrEMBL

B2GUU2, E9PSL1, Q1ERY8

Related

ENSRNOP00000015651.7, ENSRNOT00000015651.9

Conserved Domains (2) summary

COG1196
Location:546 → 1164

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl02488
Location:668 → 887

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

63693300..63714813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085262.2 → XP_038941190.1 sperm-associated antigen 5 isoform X1

UniProtKB/TrEMBL

A0A8I6A4Y3, B2GUU2, E9PSL1

Related

ENSRNOP00000085975.1, ENSRNOT00000106403.2

Conserved Domains (1) summary

COG1196
Location:515 → 1133

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]