Supv3l1 Suv3 like RNA helicase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Supv3l1provided by RGD
Official Full Name: Suv3 like RNA helicaseprovided by RGD
Primary source: RGD:1305565
See related: EnsemblRapid:ENSRNOG00000000392 AllianceGenome:RGD:1305565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable helicase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Predicted to be located in mitochondrial nucleoid and nucleus. Predicted to be part of mitochondrial degradosome. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 139.8), Kidney (RPKM 116.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30921248..30941779, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30378542..30399076, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32057530..32080170, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH140138 (e-PCR)
- UniSTS:222217

RH131421 (e-PCR)
- UniSTS:214704

RH130695 (e-PCR)
- UniSTS:213979

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, acting on acid anhydrides	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial RNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial RNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial mRNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial mRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ncRNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ncRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ncRNA surveillance	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of mitochondrial degradosome	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial degradosome	IEA Inferred from Electronic Annotation more info
part_of mitochondrial degradosome	ISO Inferred from Sequence Orthology more info
part_of mitochondrial degradosome	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase SUPV3L1, mitochondrial

Names: SUV3-like helicase; SUV3-like protein 1; suppressor of var1 3-like protein 1

NP_001012480.1

EC 3.6.4.13

XP_038954515.1

EC 3.6.4.13

XP_038954516.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012462.1 → NP_001012480.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor

See identical proteins and their annotated locations for NP_001012480.1

Status: PROVISIONAL

Source sequence(s)

BC089883

UniProtKB/Swiss-Prot

Q5EBA1

UniProtKB/TrEMBL

A0A0G2K9R3

Related

ENSRNOP00000075096.3, ENSRNOT00000080773.3

Conserved Domains (3) summary

COG0513
Location:208 → 500

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00079
Location:351 → 486

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam12513
Location:626 → 672

SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30921248..30941779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098587.2 → XP_038954515.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2K9R3

Conserved Domains (5) summary

cd18805
Location:361 → 499

SF2_C_suv3; C-terminal helicase domain of ATP-dependent RNA helicase

cd17913
Location:200 → 341

DEXQc_Suv3; DEXQ-box helicase domain of Suv3

pfam12513
Location:638 → 684

SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

pfam18114
Location:62 → 179

Suv3_N; Suv3 helical N-terminal domain

pfam18147
Location:570 → 610

Suv3_C_1; Suv3 C-terminal domain 1
XM_039098588.2 → XP_038954516.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X2

Conserved Domains (4) summary

cd18805
Location:84 → 222

SF2_C_suv3; C-terminal helicase domain of ATP-dependent RNA helicase

pfam12513
Location:361 → 407

SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

pfam18147
Location:293 → 333

Suv3_C_1; Suv3 C-terminal domain 1

cl28899
Location:1 → 64

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily