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    Fgfr1 Fibroblast growth factor receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79114, updated on 27-Dec-2024

    Summary

    Official Symbol
    Fgfr1provided by RGD
    Official Full Name
    Fibroblast growth factor receptor 1provided by RGD
    Primary source
    RGD:620713
    See related
    EnsemblRapid:ENSRNOG00000016050 AllianceGenome:RGD:620713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MFR; c-fgr; FGFR-1; bFGF-R; bFGF-R-1
    Summary
    Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Located in perinuclear region of cytoplasm. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; retinal detachment; sciatic neuropathy; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 185.8), Lung (RPKM 166.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fgfr1 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73194631..73249855, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66491930..66547161, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71265390..71319046, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC120097430 Neighboring gene uncharacterized LOC120097442

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 37
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables SH2 domain binding  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables cell adhesion molecule binding PubMed 
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables fibroblast growth factor receptor activity PubMed 
    enables heparin binding  
    enables heparin binding  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding PubMed 
    enables receptor-receptor interaction  
    enables signaling receptor binding PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 37
    Items 1 - 25 of 121
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    acts_upstream_of_or_within angiogenesis  
    involved_in animal organ development  
    acts_upstream_of_or_within auditory receptor cell development  
    acts_upstream_of_or_within blood vessel morphogenesis  
    acts_upstream_of_or_within brain development  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis  
    involved_in calcium ion homeostasis  
    acts_upstream_of cardiac muscle cell proliferation  
    involved_in cell differentiation  
    acts_upstream_of_or_within cell maturation  
    acts_upstream_of cell population proliferation  
    acts_upstream_of_or_within cell projection assembly  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to fibroblast growth factor stimulus  
    involved_in cellular response to histamine PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cementum mineralization  
    involved_in central nervous system neuron development PubMed 
    acts_upstream_of_or_within chondrocyte differentiation  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in diphosphate metabolic process  
    acts_upstream_of_or_within ear development  
    acts_upstream_of_or_within embryonic limb morphogenesis  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epithelial to mesenchymal transition  
    involved_in female pregnancy PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  
    involved_in gene expression  
    acts_upstream_of_or_within generation of neurons  
    involved_in hepatocyte growth factor receptor signaling pathway  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within inner ear morphogenesis  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within lung development  
    acts_upstream_of_or_within lung-associated mesenchyme development  
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within mesenchymal cell differentiation  
    acts_upstream_of mesenchymal cell proliferation  
    acts_upstream_of_or_within midbrain development  
    acts_upstream_of_or_within middle ear morphogenesis  
    involved_in multicellular organism development  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor production  
    acts_upstream_of_or_within negative regulation of gene expression  
    involved_in negative regulation of osteoblast differentiation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neuron projection development PubMed 
    acts_upstream_of neuron projection development  
    involved_in orbitofrontal cortex development  
    acts_upstream_of_or_within organ induction  
    acts_upstream_of_or_within outer ear morphogenesis  
    acts_upstream_of_or_within paraxial mesoderm development  
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of cardiac muscle cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation  
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell chemotaxis  
    involved_in positive regulation of fibroblast migration PubMed 
    involved_in positive regulation of hepatic stellate cell activation PubMed 
    involved_in positive regulation of macromolecule metabolic process  
    involved_in positive regulation of mesenchymal cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle DNA replication  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of parathyroid hormone secretion  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of stem cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation  
    involved_in postnatal olfactory bulb interneuron migration PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  
    involved_in regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation  
    acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within regulation of gene expression  
    acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification  
    acts_upstream_of_or_within regulation of phosphate transport  
    acts_upstream_of_or_within regulation of phosphorus metabolic process  
    involved_in regulation of postsynaptic density assembly  
    involved_in regulation of primary metabolic process  
    involved_in regulation of stem cell proliferation PubMed 
    involved_in response to ischemia PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to sodium phosphate  
    acts_upstream_of_or_within salivary gland morphogenesis  
    acts_upstream_of_or_within sensory perception of sound  
    acts_upstream_of_or_within stem cell differentiation  
    involved_in stem cell population maintenance PubMed 
    acts_upstream_of stem cell proliferation  
    involved_in tangential migration from the subventricular zone to the olfactory bulb PubMed 
    acts_upstream_of_or_within ureteric bud development  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in ventricular zone neuroblast division  
    acts_upstream_of_or_within vitamin D3 metabolic process  
    Items 1 - 25 of 121
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle  
    located_in cytosol  
    is_active_in glutamatergic synapse  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    fibroblast growth factor receptor 1
    Names
    FGF receptor-1
    basic fibroblast growth factor receptor 1
    proto-oncogene c-Fgr
    NP_077060.2
    XP_006253385.1
    XP_006253389.1
    XP_038950779.1
    XP_063131817.1
    XP_063131818.1
    XP_063131819.1
    XP_063131820.1
    XP_063131821.1
    XP_063131822.1
    XP_063131823.1
    XP_063131824.1
    XP_063131825.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024146.2NP_077060.2  fibroblast growth factor receptor 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q04589
      UniProtKB/TrEMBL
      F1LM54
      Related
      ENSRNOP00000036885.5, ENSRNOT00000029284.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73194631..73249855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253327.3XP_006253389.1  fibroblast growth factor receptor 1 isoform X8

      See identical proteins and their annotated locations for XP_006253389.1

      UniProtKB/TrEMBL
      A0A8J8YIL8, F1LPM6, Q63827
      Related
      ENSRNOP00000043459.4, ENSRNOT00000050980.7
      Conserved Domains (5) summary
      cd05098
      Location:371672
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:280309
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:164167
      Ig; Ig strand A [structural motif]
      cd05857
      Location:62156
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:164268
      Ig; Immunoglobulin domain
    2. XM_063275755.1XP_063131825.1  fibroblast growth factor receptor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8J8YIL8
    3. XM_063275754.1XP_063131824.1  fibroblast growth factor receptor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8J8YIL8
    4. XM_063275753.1XP_063131823.1  fibroblast growth factor receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8J8YIL8
    5. XM_039094851.2XP_038950779.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/Swiss-Prot
      Q04589
      Conserved Domains (6) summary
      cd05098
      Location:460761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:369398
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:253256
      Ig; Ig strand A [structural motif]
      cd04973
      Location:25118
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:151245
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:253357
      Ig; Immunoglobulin domain
    6. XM_063275751.1XP_063131821.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/Swiss-Prot
      Q04589
    7. XM_006253323.5XP_006253385.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q04589
      Conserved Domains (7) summary
      cd04973
      Location:40118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:462763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:476752
      Pkinase_Tyr; Protein tyrosine kinase
    8. XM_063275747.1XP_063131817.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04589
      UniProtKB/TrEMBL
      F1LM54
    9. XM_063275749.1XP_063131819.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04589
      UniProtKB/TrEMBL
      F1LM54
    10. XM_063275752.1XP_063131822.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/Swiss-Prot
      Q04589
    11. XM_063275750.1XP_063131820.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04589
      UniProtKB/TrEMBL
      F1LM54
    12. XM_063275748.1XP_063131818.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04589
      UniProtKB/TrEMBL
      F1LM54
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