U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Bub1b BUB1 mitotic checkpoint serine/threonine kinase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171576, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bub1bprovided by RGD
    Official Full Name
    BUB1 mitotic checkpoint serine/threonine kinase Bprovided by RGD
    Primary source
    RGD:619791
    See related
    EnsemblRapid:ENSRNOG00000007906 AllianceGenome:RGD:619791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint signaling. Predicted to act upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Predicted to be located in cytosol; perinuclear region of cytoplasm; and spindle. Predicted to be part of mitotic checkpoint complex and outer kinetochore. Predicted to be active in kinetochore and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 110.6), Spleen (RPKM 57.9) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bub1b in Genome Data Viewer
    Location:
    3q35
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126017019..126069470)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105563089..105615547)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110367949..110420471)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Bcl2 modifying factor Neighboring gene H2A.Z variant histone 2, pseudogene 1 Neighboring gene uncharacterized LOC120101639 Neighboring gene p21 (RAC1) activated kinase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein kinase activity  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in kinetochore  
    located_in kinetochore  
    part_of mitotic checkpoint complex  
    is_active_in nucleus  
    part_of outer kinetochore  
    located_in perinuclear region of cytoplasm  
    located_in spindle  

    General protein information

    Preferred Names
    mitotic checkpoint serine/threonine-protein kinase BUB1 beta
    Names
    BUB1B, mitotic checkpoint serine/threonine kinase
    budding uninhibited by benzimidazoles 1 beta
    budding uninhibited by benzimidazoles 1 homolog beta
    NP_612549.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138540.1NP_612549.1  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

      Status: VALIDATED

      Source sequence(s)
      DY567136, FN805744, JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LMI1
      Related
      ENSRNOP00000010406.8, ENSRNOT00000010406.8
      Conserved Domains (2) summary
      pfam08311
      Location:51172
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:7391035
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126017019..126069470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_352538.5 RNA Sequence

    External link. Please review our privacy policy.