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    Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50688, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cacnb1provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 1provided by RGD
    Primary source
    RGD:68382
    See related
    EnsemblRapid:ENSRNOG00000004518 AllianceGenome:RGD:68382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAB1
    Summary
    Enables several functions, including identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to voltage-gated calcium channel activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to amyloid-beta; and regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to act upstream of or within protein targeting to membrane. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 152.9), Brain (RPKM 44.1) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cacnb1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83494509..83515164, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82998182..83018838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85954138..85974764, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene transfer RNA cysteine (anticodon GCA) 37 Neighboring gene ARF like GTPase 5C Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in T-tubule  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    is_active_in presynapse  
    located_in sarcolemma  
    located_in sarcoplasmic reticulum  
    part_of voltage-gated calcium channel complex  
    part_of voltage-gated calcium channel complex PubMed 
    part_of voltage-gated calcium channel complex  
    part_of voltage-gated calcium channel complex  

    General protein information

    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-1
    Names
    brain calcium channel beta 1 subunit
    calcium channel beta 1 subunit
    calcium channel voltage-dependent subunit beta 1
    calcium channel, voltage-dependent, beta 1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017346.2NP_059042.2  voltage-dependent L-type calcium channel subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P54283
      UniProtKB/TrEMBL
      A6HIP2, G3V6K8
      Related
      ENSRNOP00000006098.4, ENSRNOT00000006098.7
      Conserved Domains (3) summary
      pfam00625
      Location:228408
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99166
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83494509..83515164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247409.5XP_006247471.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4U4, A0A8I5ZLV2
      Related
      ENSRNOP00000073177.1, ENSRNOT00000082974.3
      Conserved Domains (3) summary
      pfam00625
      Location:273453
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99166
      SH3; Src Homology 3 domain superfamily
    2. XM_006247410.4XP_006247472.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLV2, A0A8I6ASP4
      Conserved Domains (4) summary
      cd12041
      Location:52119
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      smart00072
      Location:236407
      GuKc; Guanylate kinase homologues
      pfam00625
      Location:226406
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:1152
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    3. XM_039086662.2XP_038942590.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HIP4
      Conserved Domains (1) summary
      pfam00625
      Location:1180
      Guanylate_kin; Guanylate kinase
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