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    Tlr4 toll-like receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29260, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tlr4provided by RGD
    Official Full Name
    toll-like receptor 4provided by RGD
    Primary source
    RGD:3870
    See related
    EnsemblRapid:ENSRNOG00000010522 AllianceGenome:RGD:3870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to mechanical stimulus; detection of stimulus involved in sensory perception of pain; and regulation of gene expression. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); liver disease (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; and pulpitis. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 171.1), Spleen (RPKM 101.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tlr4 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (85161247..85174882)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (80145867..80159501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (82587424..82601056)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene RNA, U6 small nuclear 1015 Neighboring gene H2A.Z variant histone 2, pseudogene 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating  
    enables identical protein binding  
    enables identical protein binding  
    enables lipopolysaccharide binding  
    enables lipopolysaccharide binding PubMed 
    enables lipopolysaccharide binding  
    enables lipopolysaccharide binding  
    enables lipopolysaccharide immune receptor activity  
    enables lipopolysaccharide immune receptor activity  
    enables lipopolysaccharide immune receptor activity  
    enables lipopolysaccharide immune receptor activity  
    enables phosphatidylinositol 3-kinase binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables signaling receptor activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transmembrane signaling receptor activity  
    Items 1 - 25 of 209
    Process Evidence Code Pubs
    acts_upstream_of B cell proliferation  
    involved_in B cell proliferation involved in immune response  
    acts_upstream_of_or_within B cell proliferation involved in immune response  
    involved_in ERK1 and ERK2 cascade  
    acts_upstream_of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within I-kappaB phosphorylation  
    involved_in I-kappaB phosphorylation  
    involved_in JNK cascade  
    acts_upstream_of JNK cascade  
    involved_in MHC class II biosynthetic process  
    acts_upstream_of MHC class II biosynthetic process  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in TRIF-dependent toll-like receptor signaling pathway  
    involved_in TRIF-dependent toll-like receptor signaling pathway  
    acts_upstream_of_or_within activation of innate immune response  
    involved_in astrocyte development  
    acts_upstream_of_or_within astrocyte development  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipoteichoic acid  
    acts_upstream_of_or_within cellular response to lipoteichoic acid  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus  
    involved_in cellular response to platelet-derived growth factor stimulus  
    involved_in cellular response to platelet-derived growth factor stimulus  
    involved_in cellular response to retinoic acid PubMed 
    involved_in cellular response to type II interferon  
    involved_in cellular response to type II interferon  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-negative bacterium  
    acts_upstream_of_or_within defense response to Gram-negative bacterium  
    involved_in detection of lipopolysaccharide  
    involved_in detection of lipopolysaccharide  
    involved_in detection of lipopolysaccharide  
    involved_in detection of lipopolysaccharide  
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain PubMed 
    involved_in gene expression  
    acts_upstream_of_or_within gene expression  
    involved_in immunoglobulin mediated immune response PubMed 
    involved_in inflammatory response  
    acts_upstream_of_or_within inflammatory response  
    involved_in inflammatory response  
    involved_in innate immune response-activating signaling pathway PubMed 
    involved_in intestinal epithelial structure maintenance  
    involved_in intestinal epithelial structure maintenance  
    involved_in leukotriene metabolic process PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway  
    NOT acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    involved_in lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of lymphocyte proliferation  
    involved_in macrophage activation  
    involved_in macrophage activation  
    involved_in microglia differentiation  
    acts_upstream_of_or_within microglia differentiation  
    involved_in microglial cell activation PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of interleukin-17 production  
    involved_in negative regulation of interleukin-17 production  
    involved_in negative regulation of interleukin-23 production  
    involved_in negative regulation of interleukin-23 production  
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of type II interferon production  
    involved_in negative regulation of type II interferon production  
    acts_upstream_of_or_within neurogenesis  
    involved_in nitric oxide biosynthetic process  
    acts_upstream_of nitric oxide biosynthetic process  
    involved_in nitric oxide production involved in inflammatory response  
    acts_upstream_of_or_within nitric oxide production involved in inflammatory response  
    involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway  
    acts_upstream_of nucleotide-binding oligomerization domain containing 1 signaling pathway  
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway  
    acts_upstream_of nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in phagocytosis  
    involved_in phagocytosis  
    involved_in positive regulation of B cell proliferation  
    acts_upstream_of_or_within positive regulation of B cell proliferation  
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of JNK cascade  
    acts_upstream_of_or_within positive regulation of JNK cascade  
    acts_upstream_of positive regulation of MAP kinase activity  
    involved_in positive regulation of MHC class II biosynthetic process  
    acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process  
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    acts_upstream_of positive regulation of NF-kappaB transcription factor activity  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus  
    involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-beta production  
    acts_upstream_of_or_within positive regulation of interferon-beta production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 production  
    involved_in positive regulation of interleukin-10 production  
    acts_upstream_of_or_within positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-6 production  
    acts_upstream_of_or_within positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    acts_upstream_of_or_within positive regulation of lymphocyte proliferation  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of macrophage cytokine production  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production  
    involved_in positive regulation of matrix metallopeptidase secretion  
    involved_in positive regulation of matrix metallopeptidase secretion  
    involved_in positive regulation of nitric oxide biosynthetic process  
    acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  
    acts_upstream_of_or_within positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  
    acts_upstream_of_or_within positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of platelet activation  
    involved_in positive regulation of platelet activation  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of smooth muscle cell migration  
    acts_upstream_of_or_within positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of stress-activated MAPK cascade  
    acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    involved_in positive regulation of type II interferon production  
    involved_in regulation of dendritic cell cytokine production  
    acts_upstream_of_or_within regulation of dendritic cell cytokine production  
    involved_in regulation of inflammatory response  
    involved_in regulation of tumor necrosis factor production PubMed 
    involved_in response to activity PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to ethanol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to fatty acid PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to gold nanoparticle PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to insulin PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in response to lipopolysaccharide  
    involved_in response to oxidative stress PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to retinoic acid PubMed 
    involved_in response to toxic substance PubMed 
    involved_in skeletal muscle contraction PubMed 
    involved_in stress-activated MAPK cascade  
    acts_upstream_of stress-activated MAPK cascade  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    acts_upstream_of_or_within toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor signaling pathway PubMed 
    involved_in toll-like receptor signaling pathway  
    involved_in wound healing involved in inflammatory response  
    involved_in wound healing involved in inflammatory response  
    Items 1 - 25 of 209
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cytoplasm  
    located_in early endosome  
    located_in endosome membrane  
    is_active_in endosome membrane  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    part_of lipopolysaccharide receptor complex  
    part_of lipopolysaccharide receptor complex  
    part_of lipopolysaccharide receptor complex  
    part_of lipopolysaccharide receptor complex  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic cup  
    located_in phagocytic cup  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    located_in ruffle  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    toll-like receptor 4
    Names
    toll4
    NP_062051.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019178.2NP_062051.2  toll-like receptor 4 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8K0ZPU7, A6J802, G3V7D8
      Related
      ENSRNOP00000014020.2, ENSRNOT00000014020.5
      Conserved Domains (4) summary
      smart00255
      Location:672813
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:23456
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:5878
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:494554
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      85161247..85174882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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