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    Stk25 serine/threonine kinase 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373542, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stk25provided by RGD
    Official Full Name
    serine/threonine kinase 25provided by RGD
    Primary source
    RGD:727809
    See related
    EnsemblRapid:ENSRNOG00000018181 AllianceGenome:RGD:727809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including establishment of Golgi localization; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Located in Golgi membrane. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 417.4), Lung (RPKM 316.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stk25 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101609218..101621458, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94161834..94174095, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100767578..100779715, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene septin 2 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene 5S ribosomal RNA Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC94619

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein homodimerization activity  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex  
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase 25
    Names
    serine/threonine kinase 25 (STE20 homolog, yeast)
    NP_908938.1
    XP_038939953.1
    XP_038939955.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_184049.1NP_908938.1  serine/threonine-protein kinase 25

      See identical proteins and their annotated locations for NP_908938.1

      Status: PROVISIONAL

      Source sequence(s)
      AY346152
      UniProtKB/TrEMBL
      A0A8I5ZQ80, F7ERC6, Q6V9V9
      Related
      ENSRNOP00000024487.4, ENSRNOT00000024487.6
      Conserved Domains (1) summary
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101609218..101621458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084025.2XP_038939953.1  serine/threonine-protein kinase 25 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    2. XM_039084027.2XP_038939955.1  serine/threonine-protein kinase 25 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:15257
      PKc_like; Protein Kinases, catalytic domain
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