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    Morc2 MORC family CW-type zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289736, updated on 27-Dec-2024

    Summary

    Official Symbol
    Morc2provided by RGD
    Official Full Name
    MORC family CW-type zinc finger 2provided by RGD
    Primary source
    RGD:1310842
    See related
    EnsemblRapid:ENSRNOG00000019624 AllianceGenome:RGD:1310842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Morc2a; Zcwcc1
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in DNA damage response; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 101.9), Thymus (RPKM 85.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Morc2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82752444..82794980)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78529603..78571375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83889138..83930263)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352784 Neighboring gene taurine up-regulated 1 Neighboring gene taurine up-regulated 1 Neighboring gene oxysterol binding protein 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134481865

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables chromatin binding  
    enables histone binding  
    enables identical protein binding  
    enables magnesium ion binding  
    enables protein homodimerization activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in heterochromatin  
    located_in nuclear matrix  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ATPase MORC2
    Names
    MORC family CW-type zinc finger protein 2
    microrchidia 2A
    zinc finger, CW-type with coiled-coil domain 1
    NP_001402037.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415108.1NP_001402037.1  ATPase MORC2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D4A2C4
      Related
      ENSRNOP00000069862.3, ENSRNOT00000078980.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82752444..82794980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005492921.2 RNA Sequence

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