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    Sall2 spalt-like transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sall2provided by RGD
    Official Full Name
    spalt-like transcription factor 2provided by RGD
    Primary source
    RGD:1309272
    See related
    EnsemblRapid:ENSRNOG00000013287 AllianceGenome:RGD:1309272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in eye development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neural tube development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in coloboma. Orthologous to human SALL2 (spalt like transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 70.2), Lung (RPKM 21.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Sall2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27494831..27512402, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (25021345..25038918, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28728471..28746042, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TOX high mobility group box family member 4 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Neighboring gene olfactory receptor family 10 subfamily G member 3C Neighboring gene ribosomal protein S19, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    sal-like protein 2
    Names
    sal-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107262.1 → NP_001100732.1  sal-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001100732.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474040
      UniProtKB/TrEMBL
      A6KEH5, D4ADE6
      Related
      ENSRNOP00000017730.4, ENSRNOT00000017730.7
      Conserved Domains (3) summary
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:690 → 711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:386 → 411
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001431420.1 → NP_001418349.1  sal-like protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K6M7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27494831..27512402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251884.5 → XP_006251946.1  sal-like protein 2 isoform X1

      Conserved Domains (3) summary
      sd00017
      Location:372 → 392
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:688 → 709
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain
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