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    Cadm3 cell adhesion molecule 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360882, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cadm3provided by RGD
    Official Full Name
    cell adhesion molecule 3provided by RGD
    Primary source
    RGD:1307035
    See related
    EnsemblRapid:ENSRNOG00000003365 AllianceGenome:RGD:1307035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Igsf4b; Necl-1
    Summary
    Predicted to enable protein homodimerization activity. Involved in synaptic membrane adhesion. Is active in GABA-ergic synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 513.9), Heart (RPKM 92.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Cadm3 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (88317124..88349718, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (85784785..85817412, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (91842311..91873126, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene mucosal pentraxin 1 Neighboring gene atypical chemokine receptor 1 Neighboring gene transfer RNA arginine (anticodon UCU) 5 Neighboring gene absent in melanoma 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in cell-cell junction  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in membrane  
    is_active_in parallel fiber to Purkinje cell synapse  
    is_active_in presynaptic membrane  
    is_active_in presynaptic membrane  

    General protein information

    Preferred Names
    cell adhesion molecule 3
    Names
    immunoglobulin superfamily, member 4B
    nectin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047103.2NP_001040568.1  cell adhesion molecule 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001040568.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q1WIM3
      UniProtKB/TrEMBL
      A0A8L2UHK9
      Related
      ENSRNOP00000004613.5, ENSRNOT00000004613.8
      Conserved Domains (5) summary
      smart00294
      Location:352367
      4.1m; putative band 4.1 homologues' binding motif
      cd05882
      Location:30124
      Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
      smart00410
      Location:237314
      IG_like; Immunoglobulin like
      pfam13895
      Location:235314
      Ig_2; Immunoglobulin domain
      cl11960
      Location:145227
      Ig; Immunoglobulin domain
    2. NM_001412817.1NP_001399746.1  cell adhesion molecule 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6ACH5
      Related
      ENSRNOP00000091652.1, ENSRNOT00000099664.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      88317124..88349718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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