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    Pcbp2 poly(rC) binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363005, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pcbp2provided by RGD
    Official Full Name
    poly(rC) binding protein 2provided by RGD
    Primary source
    RGD:1309626
    See related
    EnsemblRapid:ENSRNOG00000036852 AllianceGenome:RGD:1309626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; chromatin looping; and regulation of defense response. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Is active in postsynaptic density. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 199.1), Thymus (RPKM 177.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pcbp2 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135483702..135508254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133605375..133631312)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144077901..144103723)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479584 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene proline rich 13 Neighboring gene mitogen activated protein kinase kinase kinase 12 Neighboring gene Tarbp2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-rich single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables promoter-enhancer loop anchoring activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013223.2 → NP_001013241.1  poly(rC)-binding protein 2

      See identical proteins and their annotated locations for NP_001013241.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KBC5, D4ACH3, Q6AYU5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:284 → 359
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135483702..135508254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242420.4 → XP_006242482.1  poly(rC)-binding protein 2 isoform X21

      See identical proteins and their annotated locations for XP_006242482.1

      UniProtKB/TrEMBL
      A0A0G2KBC5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:280 → 355
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    2. XM_063263971.1 → XP_063120041.1  poly(rC)-binding protein 2 isoform X8

    3. XM_017595011.3 → XP_017450500.1  poly(rC)-binding protein 2 isoform X9

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    4. XM_017595010.3 → XP_017450499.1  poly(rC)-binding protein 2 isoform X9

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    5. XM_063263972.1 → XP_063120042.1  poly(rC)-binding protein 2 isoform X10

    6. XM_017595006.3 → XP_017450495.1  poly(rC)-binding protein 2 isoform X3

      Related
      ENSRNOP00000095172.2, ENSRNOT00000120216.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    7. XM_063263978.1 → XP_063120048.1  poly(rC)-binding protein 2 isoform X14

    8. XM_039079651.2 → XP_038935579.1  poly(rC)-binding protein 2 isoform X30

      UniProtKB/TrEMBL
      A0A0G2KBC5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:249 → 324
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    9. XM_063263994.1 → XP_063120064.1  poly(rC)-binding protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I6AP00, A6KCV9
    10. XM_006242419.5 → XP_006242481.1  poly(rC)-binding protein 2 isoform X20

      See identical proteins and their annotated locations for XP_006242481.1

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I5ZS12, Q6AYU2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    11. XM_006242425.4 → XP_006242487.1  poly(rC)-binding protein 2 isoform X29

      See identical proteins and their annotated locations for XP_006242487.1

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I6AP00, A6KCV9
      Related
      ENSRNOP00000095661.2, ENSRNOT00000099581.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    12. XM_006242427.4 → XP_006242489.1  poly(rC)-binding protein 2 isoform X33

      See identical proteins and their annotated locations for XP_006242489.1

      UniProtKB/TrEMBL
      A0A0G2KBC5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:237 → 312
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    13. XM_063264000.1 → XP_063120070.1  poly(rC)-binding protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A0G2KBC5
    14. XM_006242418.4 → XP_006242480.1  poly(rC)-binding protein 2 isoform X20

      See identical proteins and their annotated locations for XP_006242480.1

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I5ZS12, Q6AYU2
      Related
      ENSRNOP00000081612.1, ENSRNOT00000111669.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    15. XM_063263975.1 → XP_063120045.1  poly(rC)-binding protein 2 isoform X12

    16. XM_063263976.1 → XP_063120046.1  poly(rC)-binding protein 2 isoform X13

    17. XM_063263980.1 → XP_063120050.1  poly(rC)-binding protein 2 isoform X17

    18. XM_063263963.1 → XP_063120033.1  poly(rC)-binding protein 2 isoform X1

    19. XM_063263962.1 → XP_063120032.1  poly(rC)-binding protein 2 isoform X1

    20. XM_063263965.1 → XP_063120035.1  poly(rC)-binding protein 2 isoform X2

    21. XM_063263974.1 → XP_063120044.1  poly(rC)-binding protein 2 isoform X11

    22. XM_063263969.1 → XP_063120039.1  poly(rC)-binding protein 2 isoform X6

    23. XM_006242422.4 → XP_006242484.1  poly(rC)-binding protein 2 isoform X24

      See identical proteins and their annotated locations for XP_006242484.1

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I6AGT9, A6KCV8
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:268 → 343
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    24. XM_063263989.1 → XP_063120059.1  poly(rC)-binding protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A0G2KBC5
    25. XM_063264003.1 → XP_063120073.1  poly(rC)-binding protein 2 isoform X36

      UniProtKB/TrEMBL
      A0A0G2KBC5
    26. XM_063263966.1 → XP_063120036.1  poly(rC)-binding protein 2 isoform X4

    27. XM_063263970.1 → XP_063120040.1  poly(rC)-binding protein 2 isoform X7

      Related
      ENSRNOP00000085087.2, ENSRNOT00000105769.2
    28. XM_017595014.3 → XP_017450503.1  poly(rC)-binding protein 2 isoform X15

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:236 → 311
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    29. XM_063263979.1 → XP_063120049.1  poly(rC)-binding protein 2 isoform X16

    30. XM_063263973.1 → XP_063120043.1  poly(rC)-binding protein 2 isoform X10

    31. XM_063263967.1 → XP_063120037.1  poly(rC)-binding protein 2 isoform X5

    32. XM_063263983.1 → XP_063120053.1  poly(rC)-binding protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A0G2KBC5
    33. XM_063263988.1 → XP_063120058.1  poly(rC)-binding protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A0G2KBC5, A0A8I6AGT9, A6KCV8
    34. XM_063263990.1 → XP_063120060.1  poly(rC)-binding protein 2 isoform X26

      UniProtKB/TrEMBL
      A0A0G2KBC5
      Related
      ENSRNOP00000093976.2, ENSRNOT00000109477.2
    35. XM_063263995.1 → XP_063120065.1  poly(rC)-binding protein 2 isoform X30

      UniProtKB/TrEMBL
      A0A0G2KBC5
    36. XM_063263998.1 → XP_063120068.1  poly(rC)-binding protein 2 isoform X33

      UniProtKB/TrEMBL
      A0A0G2KBC5
    37. XM_063264001.1 → XP_063120071.1  poly(rC)-binding protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A0G2KBC5
    38. XM_063263999.1 → XP_063120069.1  poly(rC)-binding protein 2 isoform X34

      UniProtKB/TrEMBL
      A0A0G2KBC5, A6KCW0
    39. XM_063264004.1 → XP_063120074.1  poly(rC)-binding protein 2 isoform X36

      UniProtKB/TrEMBL
      A0A0G2KBC5
    40. XM_017595007.3 → XP_017450496.1  poly(rC)-binding protein 2 isoform X3

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    41. XM_063263981.1 → XP_063120051.1  poly(rC)-binding protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A0G2KBC5
    42. XM_063263982.1 → XP_063120052.1  poly(rC)-binding protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A0G2KBC5, D4ACH3, Q6AYU5
    43. XM_063263987.1 → XP_063120057.1  poly(rC)-binding protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A0G2KBC5
    44. XM_063263991.1 → XP_063120061.1  poly(rC)-binding protein 2 isoform X27

      UniProtKB/TrEMBL
      A0A0G2KBC5, Q4V8F6
    45. XM_063263992.1 → XP_063120062.1  poly(rC)-binding protein 2 isoform X28

      UniProtKB/TrEMBL
      A0A0G2KBC5
    46. XM_063263986.1 → XP_063120056.1  poly(rC)-binding protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A0G2KBC5
    47. XM_063263996.1 → XP_063120066.1  poly(rC)-binding protein 2 isoform X31

      UniProtKB/TrEMBL
      A0A0G2KBC5
    48. XM_063263997.1 → XP_063120067.1  poly(rC)-binding protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A0G2KBC5
    49. XM_063263964.1 → XP_063120034.1  poly(rC)-binding protein 2 isoform X1

    50. XM_063263985.1 → XP_063120055.1  poly(rC)-binding protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A0G2KBC5
      Related
      ENSRNOP00000052173.4, ENSRNOT00000055302.5