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    Rad51c RAD51 paralog C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad51cprovided by RGD
    Official Full Name
    RAD51 paralog Cprovided by RGD
    Primary source
    RGD:1563765
    See related
    EnsemblRapid:ENSRNOG00000006661 AllianceGenome:RGD:1563765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563765
    Summary
    Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA recombination and positive regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within female meiosis sister chromatid cohesion; male meiosis I; and spermatogenesis. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex and Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 49.3), Thymus (RPKM 47.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad51c in Genome Data Viewer
    Location:
    10q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72702299..72728980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72205032..72231643, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74697713..74724004, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1E Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480845 Neighboring gene uncharacterized LOC134480851 Neighboring gene transfer RNA asparagine (anticodon GUU) 9 Neighboring gene testis expressed 14, intercellular bridge forming factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. French CA, et al. J Biol Chem, 2003 Nov 14. PMID 12966089
    2. RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. Badie S, et al. J Cell Biol, 2009 May 18. PMID 19451272, Free PMC Article
    3. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. Kuznetsov S, et al. J Cell Biol, 2007 Feb 26. PMID 17312021, Free PMC Article
    4. RAD51C is required for Holliday junction processing in mammalian cells. Liu Y, et al. Science, 2004 Jan 9. PMID 14716019
    5. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. Sage JM, et al. J Biol Chem, 2010 Jun 18. PMID 20413593, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables crossover junction DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female meiosis sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Rad51C-XRCC3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad51C-XRCC3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD51 homolog 3
    Names
    Rad51 homolog c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129777.1 → NP_001123249.1  DNA repair protein RAD51 homolog 3

      See identical proteins and their annotated locations for NP_001123249.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHT5, B2RYQ3, G3V6U0
      Related
      ENSRNOP00000008846.6, ENSRNOT00000008846.7
      Conserved Domains (2) summary
      TIGR02236
      Location:12 → 339
      recomb_radA; DNA repair and recombination protein RadA
      cd01123
      Location:91 → 338
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72702299..72728980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086624.2 → XP_038942552.1  DNA repair protein RAD51 homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y707
      Related
      ENSRNOP00000078134.2, ENSRNOT00000103842.2
      Conserved Domains (2) summary
      COG1066
      Location:97 → 166
      Sms; Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]
      cd19492
      Location:145 → 348
      Rad51C; RAD51C recombinase

    2. XM_039086623.2 → XP_038942551.1  DNA repair protein RAD51 homolog 3 isoform X1

      UniProtKB/TrEMBL
      B2RYQ3
      Related
      ENSRNOP00000107561.1, ENSRNOT00000128376.1
      Conserved Domains (2) summary
      COG1066
      Location:97 → 166
      Sms; Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]
      cd19492
      Location:145 → 357
      Rad51C; RAD51C recombinase

    3. XM_063269653.1 → XP_063125723.1  DNA repair protein RAD51 homolog 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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