Psma8 proteasome 20S subunit alpha 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psma8provided by RGD
Official Full Name: proteasome 20S subunit alpha 8provided by RGD
Primary source: RGD:1311659
See related: EnsemblRapid:ENSRNOG00000030363 AllianceGenome:RGD:1311659
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311659
Summary: Predicted to be involved in meiotic cell cycle; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of meiosis I. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, alpha-subunit complex and spermatoproteasome complex. Predicted to be active in nucleus. Orthologous to human PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 129.0) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 18p13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (6138226..6202802)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (5863594..5928226)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (6114757..6182393)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of meiosis I	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spermatoproteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: proteasome subunit alpha-type 8

Names: proteasome (prosome, macropain) subunit, alpha type, 8; proteasome alpha 8 subunit-like; proteasome subunit alpha 8

NP_001102354.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108884.3 → NP_001102354.1 proteasome subunit alpha-type 8

See identical proteins and their annotated locations for NP_001102354.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A6KLT8, F1M6I7

Related

ENSRNOP00000042447.4, ENSRNOT00000044541.7

Conserved Domains (2) summary

PRK03996
Location:5 → 234

PRK03996; proteasome subunit alpha; Provisional

cd03755
Location:5 → 213

proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...