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    Il17b interleukin 17B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il17bprovided by RGD
    Official Full Name
    interleukin 17Bprovided by RGD
    Primary source
    RGD:620614
    See related
    EnsemblRapid:ENSRNOG00000019695 AllianceGenome:RGD:620614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in inflammatory response. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and signal transduction. Predicted to be located in extracellular space. Orthologous to human IL17B (interleukin 17B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 3.9), Uterus (RPKM 1.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il17b in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57411532..57415903)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55141194..55145565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57011575..57016009)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 145 Neighboring gene microRNA 143 Neighboring gene prenylcysteine oxidase 1 like Neighboring gene uncharacterized LOC134482948 Neighboring gene GrpE-like 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Li H, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639155, Free PMC Article
    2. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. Yamaguchi Y, et al. J Immunol, 2007 Nov 15. PMID 17982105

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053789.1 → NP_446241.1  interleukin-17B precursor

      See identical proteins and their annotated locations for NP_446241.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXI4, G3V8K9
      Related
      ENSRNOP00000026679.5, ENSRNOT00000026679.8
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 179
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      57411532..57415903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096543.1 → XP_038952471.1  interleukin-17B isoform X1

      UniProtKB/TrEMBL
      A6IXI5, Q9EQI7
      Conserved Domains (1) summary
      pfam06083
      Location:38 → 121
      IL17; Interleukin-17

    2. XM_039096542.2 → XP_038952470.1  interleukin-17B isoform X1

      UniProtKB/TrEMBL
      A6IXI5, Q9EQI7
      Conserved Domains (1) summary
      pfam06083
      Location:38 → 121
      IL17; Interleukin-17
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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