Fkbp6 FKBP prolyl isomerase family member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fkbp6provided by RGD
Official Full Name: FKBP prolyl isomerase family member 6provided by RGD
Primary source: RGD:1308926
See related: EnsemblRapid:ENSRNOG00000001451 AllianceGenome:RGD:1308926
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PPiase; FKBP-36
Summary: Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 140.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26947443..27026913)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21318251..21390350)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24365941..24438088)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fundamental role of Fkbp6 in homologous chromosome synapsis during male meiosis
Title: Affected homologous chromosome pairing and phosphorylation of testis specific histone, H2AX, in male meiosis under FKBP6 deficiency.
Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis.
Title: Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.

Submit: New GeneRIF Correction

General gene information

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Markers

Fkbp6 (e-PCR), detects polymorphism
- UniSTS:230790

D5S503 (e-PCR), detects polymorphism
- UniSTS:29324

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
NOT enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
NOT enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IEA Inferred from Electronic Annotation more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in piRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulatory ncRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	IEA Inferred from Electronic Annotation more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptonemal complex	IEA Inferred from Electronic Annotation more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info
located_in synaptonemal complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inactive peptidyl-prolyl cis-trans isomerase FKBP6

Names: 36 kDa FK506 binding protein; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; immunophilin FKBP36; inactive PPIase FKBP6; peptidyl-prolyl cis-trans isomerase FKBP6; rotamase

NP_001099392.1

EC 5.2.1.8

XP_006249193.1

EC 5.2.1.8

XP_008767352.1

EC 5.2.1.8

XP_017453788.1

EC 5.2.1.8

XP_063127225.1

EC 5.2.1.8

XP_063127227.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105922.1 → NP_001099392.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6

See identical proteins and their annotated locations for NP_001099392.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/Swiss-Prot

D3ZQF4

Conserved Domains (3) summary

COG0457
Location:164 → 284

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:218 → 248

TPR; TPR repeat [structural motif]

pfam00254
Location:51 → 140

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

26947443..27026913

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271155.1 → XP_063127225.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X1

Related

ENSRNOP00000083089.2, ENSRNOT00000098264.2
XM_008769130.4 → XP_008767352.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X2

See identical proteins and their annotated locations for XP_008767352.1

UniProtKB/Swiss-Prot

D3ZQF4

Conserved Domains (3) summary

COG0457
Location:164 → 284

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:218 → 248

TPR; TPR repeat [structural motif]

pfam00254
Location:51 → 140

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
XM_017598299.3 → XP_017453788.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X2

UniProtKB/Swiss-Prot

D3ZQF4

Related

ENSRNOP00000001971.2, ENSRNOT00000001971.6

Conserved Domains (3) summary

COG0457
Location:164 → 284

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:218 → 248

TPR; TPR repeat [structural motif]

pfam00254
Location:51 → 140

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
XM_006249131.5 → XP_006249193.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZW77

Conserved Domains (3) summary

COG0457
Location:164 → 284

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:218 → 248

TPR; TPR repeat [structural motif]

pfam00254
Location:51 → 140

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
XM_063271157.1 → XP_063127227.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZW77