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    Fpr1 formyl peptide receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fpr1provided by RGD
    Official Full Name
    formyl peptide receptor 1provided by RGD
    Primary source
    RGD:1310883
    See related
    EnsemblRapid:ENSRNOG00000011174 AllianceGenome:RGD:1310883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables RAGE receptor binding activity and scavenger receptor binding activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm and plasma membrane. Orthologous to human FPR1 (formyl peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 5.7), Spleen (RPKM 2.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fpr1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (67417991..67429813, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (58745019..58756776, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (59759025..59767258)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA 125a Neighboring gene hyaluronan synthase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108349528 Neighboring gene formyl peptide receptor 2 Neighboring gene formyl peptide receptor 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways. Zhang J, et al. Exp Biol Med (Maywood), 2022 Jan. PMID 34565207, Free PMC Article
    2. Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells. Wang G, et al. Sci Rep, 2016 May 13. PMID 27173446, Free PMC Article
    3. Lead optimisation of pyrazoles as novel FPR1 antagonists. Morley AD, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22094028
    4. Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. Chen JH, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16516855
    5. Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion. Liu S, et al. Int J Mol Sci, 2016 Oct 22. PMID 27782092, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
      Title: Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
    2. Reports showed that both Fpr1 and Fpr2 are expressed on NSCs and both receptors mediate the migration of neural stem cells (NSCs) in vitro and in vivo, and promote the differentiation of NSCs to neuron through F-actin polymerization.
      Title: Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
    3. ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process.
      Title: Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.
    4. analysis of pyrazoles as novel FPR1 antagonists
      Title: Lead optimisation of pyrazoles as novel FPR1 antagonists.
    5. Our results suggest that Nordy was capable of reducing the level of malignancy of glioma cells.
      Title: Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-formyl peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-formyl peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RAGE receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scavenger receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fMet-Leu-Phe receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106216.1 → NP_001099686.1  fMet-Leu-Phe receptor

      See identical proteins and their annotated locations for NP_001099686.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474033
      UniProtKB/TrEMBL
      A6KB73, D4A7Q2
      Related
      ENSRNOP00000014841.2, ENSRNOT00000014842.6
      Conserved Domains (1) summary
      pfam00001
      Location:45 → 305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      67417991..67429813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103536.2 → XP_038959464.1  fMet-Leu-Phe receptor isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:30 → 56
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:29 → 144
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006227988.5 → XP_006228050.1  fMet-Leu-Phe receptor isoform X1

      See identical proteins and their annotated locations for XP_006228050.1

      UniProtKB/TrEMBL
      A6KB73, D4A7Q2
      Conserved Domains (1) summary
      pfam00001
      Location:45 → 305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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