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    Spink7 serine peptidase inhibitor, Kazal type 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408237, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spink7provided by RGD
    Official Full Name
    serine peptidase inhibitor, Kazal type 7provided by RGD
    Primary source
    RGD:1303077
    See related
    EnsemblRapid:ENSRNOG00000032873 AllianceGenome:RGD:1303077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ecg2; Ecrg2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Orthologous to human SPINK7 (serine peptidase inhibitor Kazal type 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Spink7 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58316302..58320067, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (56045996..56049761, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57916369..57920169, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene F-box protein 38 Neighboring gene uncharacterized LOC120098287 Neighboring gene uncharacterized LOC134483040 Neighboring gene serine protease inhibitor Kazal-type 9-like Neighboring gene serine peptidase inhibitor Kazal type 13 Neighboring gene proteasome 26S subunit, non-ATPase 14, pseudogene 1 Neighboring gene serine peptidase inhibitor, Kazal type 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    serine protease inhibitor Kazal-type 7
    Names
    ECRG-2
    esophagus cancer-related gene 2 protein
    esophagus cancer-related protein 2
    serine peptidase inhibitor, Kazal type 7 (putative)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002816.3NP_001002816.2  serine protease inhibitor Kazal-type 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      F1LRJ7
      Related
      ENSRNOP00000044400.5, ENSRNOT00000040936.6
      Conserved Domains (1) summary
      cl00097
      Location:4286
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      58316302..58320067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)