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    Gsdme gasdermin E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353316, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gsdmeprovided by RGD
    Official Full Name
    gasdermin Eprovided by RGD
    Primary source
    RGD:727871
    See related
    EnsemblRapid:ENSRNOG00000009970 AllianceGenome:RGD:727871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dfna5; Dfna5h
    Summary
    Predicted to enable cardiolipin binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and wide pore channel activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; positive regulation of intracellular signal transduction; and pyroptotic cell death. Predicted to act upstream of or within inner ear auditory receptor cell differentiation. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 81.8), Brain (RPKM 63.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gsdme in Genome Data Viewer
    Location:
    4q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (80590344..80651943, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (79258799..79321129, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79934075..79999678, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555694 Neighboring gene basic proline-rich protein-like Neighboring gene protein associated with LIN7 2, MAGUK p55 family member Neighboring gene oxysterol binding protein-like 3 Neighboring gene uncharacterized LOC120102268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling. Li C, et al. Arch Toxicol, 2024 Jan. PMID 37955688, Free PMC Article
    2. The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways. Van Rossom S, et al. Front Cell Neurosci, 2015. PMID 26236191, Free PMC Article
    3. The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein. Op de Beeck K, et al. Eur J Hum Genet, 2011 Sep. PMID 21522185, Free PMC Article
    4. Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma. Kim MS, et al. Oncogene, 2008 Jun 5. PMID 18223688
    5. Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis. Zhang Y, et al. Mol Immunol, 2023 Sep. PMID 37531918

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.
      Title: Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.
    2. Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
      Title: Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables wide pore channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in granzyme-mediated programmed cell death signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyroptotic cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gasdermin-E
    Names
    DFNA5, deafness associated tumor suppressor
    deafness, autosomal dominant 5 homolog
    non-syndromic hearing impairment protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191749.1 → NP_001178678.1  gasdermin-E

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZRE3
      Related
      ENSRNOP00000081162.1, ENSRNOT00000107780.2
      Conserved Domains (1) summary
      pfam04598
      Location:1 → 458
      Gasdermin; Gasdermin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      80590344..80651943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107729.2 → XP_038963657.1  gasdermin-E isoform X3

      Conserved Domains (2) summary
      pfam04598
      Location:1 → 239
      Gasdermin; Gasdermin family
      pfam17708
      Location:237 → 409
      Gasdermin_C; Gasdermin PUB domain

    2. XM_039107728.2 → XP_038963656.1  gasdermin-E isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6Y3
      Related
      ENSRNOP00000108602.1, ENSRNOT00000134517.1
      Conserved Domains (2) summary
      pfam04598
      Location:1 → 245
      Gasdermin; Gasdermin family
      pfam17708
      Location:279 → 397
      Gasdermin_C; Gasdermin PUB domain

    3. XM_039107731.2 → XP_038963659.1  gasdermin-E isoform X6

      Conserved Domains (2) summary
      pfam04598
      Location:1 → 235
      Gasdermin; Gasdermin family
      pfam17708
      Location:233 → 299
      Gasdermin_C; Gasdermin PUB domain

    4. XM_039107730.2 → XP_038963658.1  gasdermin-E isoform X5

      UniProtKB/TrEMBL
      A0A0G2K6Y3
      Conserved Domains (2) summary
      pfam04598
      Location:1 → 245
      Gasdermin; Gasdermin family
      pfam17708
      Location:279 → 330
      Gasdermin_C; Gasdermin PUB domain

    5. XM_039107727.2 → XP_038963655.1  gasdermin-E isoform X1

      UniProtKB/TrEMBL
      A6K0M0, F1MAG0
      Conserved Domains (2) summary
      pfam04598
      Location:1 → 245
      Gasdermin; Gasdermin family
      pfam17708
      Location:279 → 464
      Gasdermin_C; Gasdermin PUB domain

    6. XM_039107726.2 → XP_038963654.1  gasdermin-E isoform X1

      UniProtKB/TrEMBL
      A6K0M0, F1MAG0
      Related
      ENSRNOP00000013264.8, ENSRNOT00000013264.9
      Conserved Domains (2) summary
      pfam04598
      Location:1 → 245
      Gasdermin; Gasdermin family
      pfam17708
      Location:279 → 464
      Gasdermin_C; Gasdermin PUB domain

    7. XM_063286213.1 → XP_063142283.1  gasdermin-E isoform X4

      UniProtKB/TrEMBL
      A0A0G2K6Y3
      Related
      ENSRNOP00000073987.2, ENSRNOT00000086453.3

    8. XM_039107732.2 → XP_038963660.1  gasdermin-E isoform X7

      Conserved Domains (1) summary
      pfam04598
      Location:1 → 234
      Gasdermin; Gasdermin family

    RNA

    1. XR_005503244.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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