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    ZNF772 zinc finger protein 772 [ Homo sapiens (human) ]

    Gene ID: 400720, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ZNF772provided by HGNC
    Official Full Name
    zinc finger protein 772provided by HGNC
    Primary source
    HGNC:HGNC:33106
    See related
    Ensembl:ENSG00000197128 AllianceGenome:HGNC:33106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.7), testis (RPKM 0.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF772 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57469586..57477566, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60566631..60574608, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57980954..57988934, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 1 Neighboring gene vomeronasal 1 receptor 107 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:57988249-57989448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57998906-57999406 Neighboring gene zinc finger protein 419 Neighboring gene zinc finger protein 773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. [Correlation between DNA Methylation of ZNF772 Promoter Region and Cervical Cancer]. Li M, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2020 Apr 28. PMID 32385021
    2. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Xu D, et al. Nature, 2020 Apr. PMID 32322062
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Correlation between DNA Methylation of ZNF772 Promoter Region and Cervical Cancer].
      Title: [Correlation between DNA Methylation of ZNF772 Promoter Region and Cervical Cancer].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686I1569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 772

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051489.1 RefSeqGene

      Range
      5005..12985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024596.3 → NP_001019767.1  zinc finger protein 772 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC003005, AC004076, BC150292, BX647068
      Consensus CDS
      CCDS33133.1
      UniProtKB/Swiss-Prot
      A6NJK9, B4DH56, B4DYS0, Q68DY9
      Related
      ENSP00000341165.4, ENST00000343280.8
      Conserved Domains (6) summary
      smart00349
      Location:27 → 87
      KRAB; krueppel associated box
      COG5048
      Location:158 → 464
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:266 → 288
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:280 → 305
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001144068.2 → NP_001137540.1  zinc finger protein 772 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC003005, AC004076, AK302574, BC150292, BX647068
      Consensus CDS
      CCDS46210.1
      UniProtKB/Swiss-Prot
      Q68DY9
      Related
      ENSP00000348992.3, ENST00000356584.8
      Conserved Domains (6) summary
      smart00349
      Location:27 → 68
      KRAB; krueppel associated box
      COG5048
      Location:117 → 423
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:225 → 247
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:239 → 264
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001330613.2 → NP_001317542.1  zinc finger protein 772 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC003005, AC004076, AK294941, BC150292, DB450372
      Consensus CDS
      CCDS82406.1
      UniProtKB/Swiss-Prot
      Q68DY9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57469586..57477566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258944.5 → XP_005259001.1  zinc finger protein 772 isoform X2

      UniProtKB/Swiss-Prot
      Q68DY9
      Related
      ENSP00000395967.2, ENST00000427512.6
      Conserved Domains (4) summary
      COG5048
      Location:46 → 352
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156 → 176
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:154 → 176
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:168 → 193
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011526980.4 → XP_011525282.1  zinc finger protein 772 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:103 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 233
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:211 → 233
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:225 → 250
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60566631..60574608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321027.1 → XP_054177002.1  zinc finger protein 772 isoform X2

      UniProtKB/TrEMBL
      B4DWJ5

    2. XM_054321026.1 → XP_054177001.1  zinc finger protein 772 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68DY9.2 GenPept UniProtKB/Swiss-Prot:Q68DY9

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