Scg2 secretogranin II [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scg2provided by RGD
Official Full Name: secretogranin IIprovided by RGD
Primary source: RGD:3626
See related: EnsemblRapid:ENSRNOG00000015055 AllianceGenome:RGD:3626
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chcg
Summary: Predicted to enable chemoattractant activity and cytokine activity. Predicted to be involved in several processes, including eosinophil chemotaxis; induction of positive chemotaxis; and negative regulation of apoptotic process. Located in secretory granule. Orthologous to human SCG2 (secretogranin II). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 456.8) and Adrenal (RPKM 303.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (88251531..88257208, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (80803074..80808646, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (85237460..85243024, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EM66 (peptide derived from SCG2) gene expression is modulated by a negative energy status and suggest interactions between EM66 and NPY to regulate food intake through the POMC system.
Title: Effect of food deprivation on the hypothalamic gene expression of the secretogranin II-derived peptide EM66 in rat.
Manserin localizes to secretory cells in the oviduct and may be involved in stress-induced gynecological disorders.
Title: Localization of manserin, a secretogranin II-derived neuropeptide, in the oviduct of female rats.
Manserin localizes to rat thyroid follicular epithelial cells and also to some parafollicular cells
Title: Subtype-specific parafollicular localization of the neuropeptide manserin in the rat thyroid gland.
The secretogranin II fragment secretoneurin reduces ischemia/reperfusion injury in the isolated perfused rat heart.
Title: Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties.
results indicate that manserin, occurring in the endocrine pancreas, may have a potential role in the endocrine system
Title: Manserin, a secretogranin II-derived peptide, distributes in the rat endocrine pancreas colocalized with islet-cell specific manner.
SgII is a critical factor for the regulation of DCG biogenesis in neuroendocrine cells
Title: Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.
analysis of the N- and C-terminal alpha-helical domains in secretogranin II
Title: Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains.
MAPK signaling and ATF3 action are essential for full SgII promoter activation by GnRHa through a canonical CRE
Title: 3', 5'-cyclic adenosine 5'-monophosphate response element-dependent transcriptional regulation of the secretogranin II gene promoter depends on gonadotropin-releasing hormone-induced mitogen-activated protein kinase activation and the transactivator activating transcription factor 3.
A novel 40 amino acid neuropeptide designated manserin (residues 529-568 of secretogranin II) localizes to endocrine cells of the pituitary anterior lobe and is observed in neuronal cells of hypothalamic nuclei and neurons in the median eminence.
Title: Manserin, a novel peptide from secretogranin II in the neuroendocrine system.
CgA and SgII (chromogranin A and secretogranin II) mRNA were expressed in both mammary adenocarcinoma and fibroadenoma tumors, but SgI (secretogranin I) mRNA was not detected in either.
Title: Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

RH139367 (e-PCR)
- UniSTS:221453

Scg2 (e-PCR), detects polymorphism
- UniSTS:507207

X68837 (e-PCR)
- UniSTS:163255

Scg2 (e-PCR), detects polymorphism
- UniSTS:144372

D9Wox33 (e-PCR)
- UniSTS:240382

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: secretogranin-2

Names: Chromogranin C (Secretogranin II); chromogranin-C; secretogranin II (chromogranin C); sgII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022669.2 → NP_073160.2 secretogranin-2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P10362

UniProtKB/TrEMBL

A0A8I6A821, A6JW74

Related

ENSRNOP00000078659.1, ENSRNOT00000105728.2

Conserved Domains (1) summary

pfam01271
Location:27 → 616

Granin; Granin (chromogranin or secretogranin)