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    Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4f1provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 1provided by RGD
    Primary source
    RGD:70926
    See related
    EnsemblRapid:ENSRNOG00000004786 AllianceGenome:RGD:70926
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp4f2; Cyp4f14
    Summary
    Enables several functions, including arachidonate binding activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 856.7) and Kidney (RPKM 348.6) See more
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    Genomic context

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    See Cyp4f1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12661357..12672952, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (12010850..12022497, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (15179472..15191113, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 like 5 Neighboring gene zinc finger protein 14-like Neighboring gene nuclear transport factor 2 like 1 Neighboring gene zinc finger protein 870 Neighboring gene uncharacterized LOC102548621 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and regulation of the rat hepatic CYP4F1 gene by peroxisome proliferators. Donelson E, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18262487
    2. Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. Imaoka S, et al. Drug Metab Pharmacokinet, 2005 Dec. PMID 16415532
    3. Purification and characterization of recombinant rat hepatic CYP4F1. Kikuta Y, et al. Arch Biochem Biophys, 1999 Sep 15. PMID 10486137
    4. Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats. Harris AJ, et al. Carcinogenesis, 1998 Aug. PMID 9744542
    5. CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury. Wang Y, et al. J Neurotrauma, 2008 Oct. PMID 18847377, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The reduced expression of hepatic alpha-TTP and CYP4F2 genes probably leads to decreased plasma alpha-tocopherol levels and elevated alpha-tocopherol levels in the liver of streptozotocin rats.
      Title: α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.
    2. In clofibrate treated rats HNF4alpha binds during gene repression, suggesting differential regulation of the CYP4F1 gene in vivo and in cell lines.
      Title: Genomic structure and regulation of the rat hepatic CYP4F1 gene by peroxisome proliferators.
    3. CYP4F1 is more highly expressed in the renal cortex than medulla of the spontaneously hypertensive (SHR) rat and may be a critical enzyme in the development of this rat strain.
      Title: Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93476

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arachidonate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate omega-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in icosanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukotriene B4 catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in omega-hydroxylase P450 pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4F1
    Names
    CYPIVF1
    P450-A3
    cytochrome P450, family 4, subfamily F, polypeptide 2
    cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)
    cytochrome P450-A3
    leukotriene-B4 20-monooxygenase
    NP_062569.2
    XP_008763402.1
    XP_008763403.1
    XP_038935719.1
    XP_038935720.1
    XP_063120235.1
    XP_063120236.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019623.2 → NP_062569.2  cytochrome P450 4F1

      See identical proteins and their annotated locations for NP_062569.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081808
      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8
      Related
      ENSRNOP00000006533.3, ENSRNOT00000006533.7
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      12661357..12672952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765180.4 → XP_008763402.1  cytochrome P450 4F1 isoform X1

      See identical proteins and their annotated locations for XP_008763402.1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    2. XM_063264166.1 → XP_063120236.1  cytochrome P450 4F1 isoform X1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8

    3. XM_008765181.3 → XP_008763403.1  cytochrome P450 4F1 isoform X1

      See identical proteins and their annotated locations for XP_008763403.1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    4. XM_039079792.2 → XP_038935720.1  cytochrome P450 4F1 isoform X1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F

    5. XM_063264165.1 → XP_063120235.1  cytochrome P450 4F1 isoform X1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8

    6. XM_039079791.2 → XP_038935719.1  cytochrome P450 4F1 isoform X1

      UniProtKB/Swiss-Prot
      P33274
      UniProtKB/TrEMBL
      A6K970, F7F3E1, Q66HK8
      Conserved Domains (1) summary
      cd20679
      Location:74 → 515
      CYP4F; cytochrome P450 family 4, subfamily F
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33274.1 GenPept UniProtKB/Swiss-Prot:P33274

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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