Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4a8provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 8provided by RGD
Primary source: RGD:628846
See related: EnsemblRapid:ENSRNOG00000008842 AllianceGenome:RGD:628846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp4a12
Summary: Enables fatty acid omega-hydroxylase activity. Involved in fatty acid metabolic process; kidney development; and response to testosterone. Located in endoplasmic reticulum membrane. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 662.9) See more
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Genomic context

Location:: 5q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (133938882..133970226, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128702130..128733476, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (133978953..134008255, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased vascular tone brought about by induction of CYP4A8 and enhanced production of 20-HETE may constitute important factors in androgen-induced hypertension.
Title: Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension.

Submit: New GeneRIF Correction

General gene information

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Markers

AA893011 (e-PCR)
- UniSTS:249991

RH135045 (e-PCR)
- UniSTS:218322

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cytochrome P450 4A12

Names: CYPIVA12; CYPIVA8; P450-KP1; P450-PP1; cytochrome P450, 4a12; cytochrome P450-KP1; cytochrome P450-PP1

NP_113793.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.