Stk3 serine/threonine kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk3provided by RGD
Official Full Name: serine/threonine kinase 3provided by RGD
Primary source: RGD:68412
See related: EnsemblRapid:ENSRNOG00000011278 AllianceGenome:RGD:68412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MST2
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and transcription regulator activator activity. Predicted to be involved in several processes, including hippo signaling; protein localization to organelle; and regulation of signal transduction. Predicted to act upstream of or within several processes, including chordate embryonic development; hepatocyte apoptotic process; and positive regulation of signal transduction. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 64.2), Adrenal (RPKM 61.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (67938341..68208472, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (66053209..66323292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (73617926..73883896, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle.
Title: STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140000 (e-PCR)
- UniSTS:222082

WI-20184 (e-PCR)
- UniSTS:54716

BF403719 (e-PCR)
- UniSTS:246506

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activator activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocardium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocardium development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organ growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in neural tube formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube formation	ISO Inferred from Sequence Orthology more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in primitive hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primitive hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase 3

Names: MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine kinase 3 (STE20 homolog, yeast)

NP_113923.2

EC 2.7.11.1

XP_008763681.1

EC 2.7.11.1

XP_008763684.1

EC 2.7.11.1

XP_038935793.1

EC 2.7.11.1

XP_038935794.1

EC 2.7.11.1

XP_038935795.1

EC 2.7.11.1

XP_063120292.1

EC 2.7.11.1

XP_063120293.1

EC 2.7.11.1

XP_063120294.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031735.2 → NP_113923.2 serine/threonine-protein kinase 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O54748

UniProtKB/TrEMBL

B1WBQ5, F7ER57

Related

ENSRNOP00000062778.1, ENSRNOT00000065722.5

Conserved Domains (2) summary

cd06612
Location:23 → 278

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

pfam11629
Location:437 → 484

Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

67938341..68208472 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765462.4 → XP_008763684.1 serine/threonine-protein kinase 3 isoform X6

Conserved Domains (3) summary

smart00220
Location:27 → 167

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:326 → 373

Mst1_SARAH; C terminal SARAH domain of Mst1

cl21453
Location:23 → 167

PKc_like; Protein Kinases, catalytic domain
XM_039079866.2 → XP_038935794.1 serine/threonine-protein kinase 3 isoform X5

Conserved Domains (2) summary

pfam11629
Location:370 → 414

Mst1_SARAH; C terminal SARAH domain of Mst1

cl21453
Location:23 → 167

PKc_like; Protein Kinases, catalytic domain
XM_039079865.2 → XP_038935793.1 serine/threonine-protein kinase 3 isoform X1

UniProtKB/Swiss-Prot

O54748

Conserved Domains (2) summary

cd06612
Location:23 → 278

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

pfam11629
Location:481 → 525

Mst1_SARAH; C terminal SARAH domain of Mst1
XM_063264222.1 → XP_063120292.1 serine/threonine-protein kinase 3 isoform X3

UniProtKB/TrEMBL

A0A8I6G6P5
XM_039079867.1 → XP_038935795.1 serine/threonine-protein kinase 3 isoform X7

Conserved Domains (2) summary

pfam11629
Location:250 → 294

Mst1_SARAH; C terminal SARAH domain of Mst1

cl21453
Location:1 → 47

PKc_like; Protein Kinases, catalytic domain
XM_063264223.1 → XP_063120293.1 serine/threonine-protein kinase 3 isoform X4

UniProtKB/Swiss-Prot

O54748
XM_008765459.4 → XP_008763681.1 serine/threonine-protein kinase 3 isoform X2

UniProtKB/Swiss-Prot

O54748

Related

ENSRNOP00000107813.1, ENSRNOT00000131594.1

Conserved Domains (2) summary

cd06612
Location:23 → 278

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:27 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain
XM_063264224.1 → XP_063120294.1 serine/threonine-protein kinase 3 isoform X8