Ctsk cathepsin K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctskprovided by RGD
Official Full Name: cathepsin Kprovided by RGD
Primary source: RGD:61810
See related: EnsemblRapid:ENSRNOG00000021155 AllianceGenome:RGD:61810
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including collagen binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and fibronectin binding activity. Involved in several processes, including bone resorption; cellular response to transforming growth factor beta stimulus; and cellular response to zinc ion starvation. Located in extracellular space. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 264.0), Testes (RPKM 141.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185747548..185758512)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (183058586..183069551)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196655469..196666447)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin
Title: Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K.
Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
Title: Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme.
Title: Species differences between human and rat in the substrate specificity of cathepsin K.
The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined.
Title: Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar.
insulin-dependent diabetes mellitus contributes to bone loss through changes in gene expression of TRAP and cathepsin K in osteoclasts as well as osteocalcin in osteoblasts
Title: Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats.
In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance.
Title: Modulation of hypotensive effects of kinins by cathepsin K.
cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies
Title: Expression and localization of cathepsin k in adult rat sertoli cells.

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General gene information

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Markers

RH135289 (e-PCR)
- UniSTS:218566

RH130167 (e-PCR)
- UniSTS:213454

UniSTS:496617 (e-PCR)
- UniSTS:496617

Ctsk (e-PCR), detects polymorphism
- UniSTS:496617

Ctsk (e-PCR), detects polymorphism
- UniSTS:498425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	TAS Traceable Author Statement more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intramembranous ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mononuclear cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cathepsin K

NP_113748.1

EC 3.4.22.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031560.2 → NP_113748.1 cathepsin K precursor

See identical proteins and their annotated locations for NP_113748.1

Status: PROVISIONAL

Source sequence(s)

BC078793

UniProtKB/Swiss-Prot

O35186

UniProtKB/TrEMBL

A6K2Z6

Related

ENSRNOP00000111490.1, ENSRNOT00000157112.1

Conserved Domains (2) summary

smart00848
Location:26 → 85

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:115 → 327

Peptidase_C1; Papain family cysteine protease