Kcnk4 potassium two pore domain channel subfamily K member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk4provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 4provided by RGD
Primary source: RGD:621449
See related: EnsemblRapid:ENSRNOG00000021140 AllianceGenome:RGD:621449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KT4.1; TRAAK
Summary: Enables mechanosensitive potassium channel activity; potassium ion leak channel activity; and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and detection of mechanical stimulus involved in sensory perception of touch. Located in node of Ranvier and plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 34.5), Testes (RPKM 4.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213547577..213558706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204117941..204129494, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222182997..222192139, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
Title: Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
we show that TREK-1 and TRAAK are clustered at nodes of Ranvier of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas
Title: TREK-1 and TRAAK Are Principal K(+) Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats.
Title: Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
Upregulation of TRAAK was observed in the spinal cord of DO rats after chronic PBOO, which may exert a protective effect against DO by suppressing the excitability of neurons.
Title: Enhanced expression of TWIK-related arachidonic acid-activated K+ channel in the spinal cord of detrusor overactivity rats after partial bladder outlet obstruction.
present results revealed that TREK-1, TREK-2 and TRAAK channels colocalized with thermosensitive TRP channels in some small trigeminal ganglion neurons
Title: Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells.
TRAAK is a temperature-sensitive channel active at physiological body temperature, and therefore would contribute to the background K+ conductance and regulate cell excitability in response to various physical and chemical stimuli.
Title: Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK.
Localization of the Traak protein was studied.
Title: Heterogeneous expression of TASK-3 and TRAAK in rat paraganglionic cells.
TRAAK immunoreactivity is detected in type I cells of the carotid body and nerve fibers.
Title: TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body.
In hippocampus, the gene expressions of TREK-1 and TRAAK were increased markedly at 3 days (97% and 87%, respectively) and 30 days (63% and 47%, respectively) after ischemia.
Title: Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia.

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General gene information

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Markers

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:547597

RH138174 (e-PCR)
- UniSTS:220261

UniSTS:166286 (e-PCR)
- UniSTS:166286

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:166286

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mechanosensitive potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive potassium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables temperature-gated cation channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to alkaline pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to arachidonate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to arachidonate	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to temperature stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in response to ultrasound	ISO Inferred from Sequence Orthology more info
involved_in response to ultrasound	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of temperature stimulus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 4

Names: TWIK-related arachidonic acid-stimulated potassium channel protein; potassium channel, two pore domain subfamily K, member 4; potassium inwardly-rectifying channel, subfamily K, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053804.3 → NP_446256.3 potassium channel subfamily K member 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

G3V8V5, Q924I4

Related

ENSRNOP00000028704.1, ENSRNOT00000028704.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213547577..213558706 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760055.4 → XP_008758277.1 potassium channel subfamily K member 4 isoform X2

See identical proteins and their annotated locations for XP_008758277.1

UniProtKB/Swiss-Prot

G3V8V5, Q924I4

Conserved Domains (1) summary

pfam07885
Location:89 → 143

Ion_trans_2; Ion channel
XM_006230634.5 → XP_006230696.1 potassium channel subfamily K member 4 isoform X1

Conserved Domains (1) summary

pfam07885
Location:115 → 169

Ion_trans_2; Ion channel
XM_063263776.1 → XP_063119846.1 potassium channel subfamily K member 4 isoform X2

UniProtKB/Swiss-Prot

G3V8V5, Q924I4
XM_039109360.2 → XP_038965288.1 potassium channel subfamily K member 4 isoform X4

Conserved Domains (1) summary

pfam07885
Location:48 → 126

Ion_trans_2; Ion channel
XM_063263854.1 → XP_063119924.1 potassium channel subfamily K member 4 isoform X3