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    Igfbp7 insulin-like growth factor binding protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igfbp7provided by RGD
    Official Full Name
    insulin-like growth factor binding protein 7provided by RGD
    Primary source
    RGD:1306201
    See related
    AllianceGenome:RGD:1306201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mac25; IGFBPRP1; IGFBP-rP1; IGFBP-RP-1
    Summary
    Predicted to enable receptor ligand activity. Involved in several processes, including embryo implantation; response to cortisol; and response to retinoic acid. Located in extracellular space. Biomarker of metabolic dysfunction-associated steatotic liver disease and renal cell carcinoma. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 3789.4), Lung (RPKM 1767.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igfbp7 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31091681..31151623)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (30737414..30797317)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33010300..33070193)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551339 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134481901 Neighboring gene RAN guanine nucleotide release factor, pseudogene 3 Neighboring gene transfer RNA cysteine (anticodon GCA) 38 Neighboring gene ribosomal protein L39, pseudogene 12 Neighboring gene uncharacterized LOC120096729 Neighboring gene RNA polymerase II subunit B Neighboring gene nitric oxide associated 1 Neighboring gene RE1-silencing transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease. Yao K, et al. Hepatol Commun, 2022 Jul. PMID 35312185, Free PMC Article
    2. Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease. Gao R, et al. Front Endocrinol (Lausanne), 2022. PMID 36034446, Free PMC Article
    3. Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease. Li T, et al. Lipids Health Dis, 2019 Dec 5. PMID 31805951, Free PMC Article
    4. Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts. Pereira RC, et al. Endocrinology, 1999 Jan. PMID 9886829
    5. Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts. Pereira RC, et al. Endocrinology, 1999 May. PMID 10218947

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IGFBP7 contributes to epithelial-mesenchymal transition of HPAEpiC cells in response to radiation.
      Title: IGFBP7 contributes to epithelial-mesenchymal transition of HPAEpiC cells in response to radiation.
    2. These findings suggest that IGFBP-7 negatively regulates differentiation of oligodendrocyte precursor cells via regulation of Wnt/beta-Catenin signaling.
      Title: IGFBP-7 inhibits the differentiation of oligodendrocyte precursor cells via regulation of Wnt/β-Catenin signaling.
    3. Suggest a potentially mutual regulation between IGFBPrP1 and TGFbeta1, which activates hepatic stellate cells and extracellular matrix deposition.
      Title: Interaction between insulin-like growth factor binding protein-related protein 1 and transforming growth factor beta 1 in primary hepatic stellate cells.
    4. possible roles of IGFBP7 in the corticotrophs
      Title: Expression of IGFBP7 mRNA in corticotrophs in the anterior pituitary of adrenalectomized rats.
    5. IGFBPt suppresses estrogen production in granulosa cells.
      Title: Effect of insulin-like growth factor-binding protein 7 on steroidogenesis in granulosa cells derived from equine chorionic gonadotropin-primed immature rat ovaries.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in embryo implantation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cortisol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013048.1 → NP_001013066.1  insulin-like growth factor-binding protein 7 precursor

      See identical proteins and their annotated locations for NP_001013066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086582
      UniProtKB/TrEMBL
      A6JCU7, Q5RJM3
      Conserved Domains (4) summary
      cd00096
      Location:176 → 261
      Ig; Immunoglobulin domain
      smart00121
      Location:31 → 66
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:110 → 155
      KAZAL; Kazal type serine protease inhibitors
      pfam07679
      Location:159 → 264
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31091681..31151623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272904.1 → XP_063128974.1  insulin-like growth factor-binding protein 7 isoform X1

      UniProtKB/TrEMBL
      A6JCU7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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