Ahsa1 activator of Hsp90 ATPase activity 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahsa1provided by RGD
Official Full Name: activator of Hsp90 ATPase activity 1provided by RGD
Primary source: RGD:1589285
See related: EnsemblRapid:ENSRNOG00000048981 AllianceGenome:RGD:1589285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATPase activator activity; Hsp90 protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in positive regulation of ATP-dependent activity and protein folding. Predicted to be active in cytosol. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 385.0), Heart (RPKM 375.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (112644287..112652290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (106913296..106921347)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (111296168..111304224)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G62105 (e-PCR)
- UniSTS:139141

RH98219 (e-PCR)
- UniSTS:88508

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activator of 90 kDa heat shock protein ATPase homolog 1

Names: AHA1, activator of heat shock 90kDa protein ATPase homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115034.1 → NP_001108506.1 activator of 90 kDa heat shock protein ATPase homolog 1

See identical proteins and their annotated locations for NP_001108506.1

Status: PROVISIONAL

Source sequence(s)

CH473982

UniProtKB/TrEMBL

B0BN63, M0R811

Related

ENSRNOP00000065600.1, ENSRNOT00000075425.3

Conserved Domains (3) summary

cd08892
Location:208 → 333

SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins

smart01000
Location:29 → 158

Aha1_N; Activator of Hsp90 ATPase, N-terminal

COG5580
Location:19 → 337

COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

112644287..112652290

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594356.3 → XP_017449845.1 activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1

UniProtKB/TrEMBL

A6JE98

Conserved Domains (1) summary

cd08892
Location:73 → 198

SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins