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    Cnst consortin, connexin sorting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498297, updated on 9-Dec-2024

    Summary

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    Symbol
    Cnstprovided by RGD
    Full Name
    consortin, connexin sorting proteinprovided by RGD
    Primary source
    RGD:1564833
    See related
    EnsemblRapid:ENSRNOG00000002710 AllianceGenome:RGD:1564833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564833
    Summary
    Predicted to enable connexin binding activity and phosphatase binding activity. Predicted to be involved in positive regulation of Golgi to plasma membrane protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane; trans-Golgi network; and transport vesicle. Orthologous to human CNST (consortin, connexin sorting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 196.4), Heart (RPKM 84.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnst in Genome Data Viewer
    Location:
    13q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93828694..93905497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91296740..91373531)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97838325..97915131)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene ribosomal protein L23,pseudogene 6 Neighboring gene uncharacterized LOC108352581 Neighboring gene transcription factor B2, mitochondrial Neighboring gene saccharopine dehydrogenase (putative) Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. del Castillo FJ, et al. Hum Mol Genet, 2010 Jan 15. PMID 19864490, Free PMC Article
    2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables connexin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables connexin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    consortin; consortin, connexin sorting protein
    Names
    consortin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430792.1 → NP_001417721.1  consortin, connexin sorting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    2. NM_001430793.1 → NP_001417722.1  consortin, connexin sorting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGF5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      93828694..93905497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_573525.8 → XP_573525.5  consortin isoform X1

      See identical proteins and their annotated locations for XP_573525.5

      UniProtKB/TrEMBL
      A0A8I5ZKG8
      Related
      ENSRNOP00000078188.1, ENSRNOT00000119104.2
      Conserved Domains (1) summary
      pfam15281
      Location:673 → 784
      Consortin_C; Consortin C-terminus

    2. XM_039091465.2 → XP_038947393.1  consortin isoform X3

      Conserved Domains (1) summary
      pfam15281
      Location:462 → 573
      Consortin_C; Consortin C-terminus

    3. XM_006250411.5 → XP_006250473.1  consortin isoform X2

      See identical proteins and their annotated locations for XP_006250473.1

      UniProtKB/TrEMBL
      D3ZKK3
      Conserved Domains (1) summary
      pfam15281
      Location:608 → 719
      Consortin_C; Consortin C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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