Tead1 TEA domain transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tead1provided by RGD
Official Full Name: TEA domain transcription factor 1provided by RGD
Primary source: RGD:1549742
See related: EnsemblRapid:ENSRNOG00000015488 AllianceGenome:RGD:1549742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TEF-1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including hippo signaling; positive regulation of cell growth; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic organ development; positive regulation of macromolecule metabolic process; and transition between fast and slow fiber. Predicted to be located in nucleoplasm. Predicted to be part of TEAD-YAP complex. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 148.6), Muscle (RPKM 145.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (176227175..176445122)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (166791900..167010591)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (177495500..177714795)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].
Title: [CRISPR/Cas9-mediated TEAD1 knockout induces phenotypic modulation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].
Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize hepatocellular carcinoma (HCC) with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC cells
Title: Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
the first evidence demonstrating that TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with myocardin binding to SRF.
Title: The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function.
Transcription enhancer factor 1 (Tef-1)binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.
Title: Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat280 (e-PCR), detects polymorphism
- UniSTS:227094

AU046756 (e-PCR)
- UniSTS:111161

D1Rat55 (e-PCR)
- UniSTS:118596

BE107218 (e-PCR)
- UniSTS:261453

UniSTS:224609 (e-PCR)
- UniSTS:224609

D1Got160 (e-PCR)
- UniSTS:115866

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional enhancer factor TEF-1

Names: TEA domain family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198589.2 → NP_001185518.1 transcriptional enhancer factor TEF-1

See identical proteins and their annotated locations for NP_001185518.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZKU4, A6I870

Related

ENSRNOP00000021020.4, ENSRNOT00000021020.6

Conserved Domains (2) summary

smart00426
Location:15 → 82

TEA; TEA domain

pfam17725
Location:204 → 412

YBD; YAP binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

176227175..176445122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267472.1 → XP_063123542.1 transcriptional enhancer factor TEF-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2N3, A0A8I5ZKU4
XM_063267482.1 → XP_063123552.1 transcriptional enhancer factor TEF-1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZKU4
XM_063267476.1 → XP_063123546.1 transcriptional enhancer factor TEF-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2N3, A0A8I5ZKU4
XM_063267458.1 → XP_063123528.1 transcriptional enhancer factor TEF-1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZMT2
XM_063267471.1 → XP_063123541.1 transcriptional enhancer factor TEF-1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZMT2
XM_063267456.1 → XP_063123526.1 transcriptional enhancer factor TEF-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2N3, A0A8I5ZKU4
XM_063267467.1 → XP_063123537.1 transcriptional enhancer factor TEF-1 isoform X3

UniProtKB/TrEMBL

A0A8I5Y8C5, A0A8I5ZKU4

Related

ENSRNOP00000077946.1, ENSRNOT00000104208.2
XM_039082788.2 → XP_038938716.1 transcriptional enhancer factor TEF-1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZM31

Related

ENSRNOP00000092848.1, ENSRNOT00000105758.2

Conserved Domains (2) summary

smart00426
Location:15 → 74

TEA; TEA domain

pfam17725
Location:179 → 387

YBD; YAP binding domain
XM_039082763.2 → XP_038938691.2 transcriptional enhancer factor TEF-1 isoform X7

UniProtKB/TrEMBL

A0A8I5ZM31, A0A8I6A1B4