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    Kbtbd4 kelch repeat and BTB domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kbtbd4provided by RGD
    Official Full Name
    kelch repeat and BTB domain containing 4provided by RGD
    Primary source
    RGD:1310234
    See related
    EnsemblRapid:ENSRNOG00000009397 AllianceGenome:RGD:1310234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human KBTBD4 (kelch repeat and BTB domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 108.2), Brain (RPKM 106.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kbtbd4 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97339500..97345599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (76883671..76889769)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79728759..79735838)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 4 Neighboring gene family with sequence similarity 180 member B Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 4
    Names
    kelch repeat and BTB (POZ) domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399486.1 → NP_001386415.1  kelch repeat and BTB domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HN91
      Conserved Domains (4) summary
      PHA03098
      Location:47 → 479
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:279 → 314
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:13 → 152
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:142 → 229
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    2. NM_001399487.1 → NP_001386416.1  kelch repeat and BTB domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97339500..97345599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234507.5 → XP_006234569.1  kelch repeat and BTB domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006234569.1

      UniProtKB/TrEMBL
      A6HN90
      Related
      ENSRNOP00000060210.2, ENSRNOT00000068124.4
      Conserved Domains (4) summary
      PHA03098
      Location:63 → 495
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:295 → 330
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:29 → 168
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:158 → 245
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    2. XM_039104897.2 → XP_038960825.1  kelch repeat and BTB domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A6HN91
      Conserved Domains (4) summary
      PHA03098
      Location:47 → 479
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:279 → 314
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:13 → 152
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:142 → 229
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    3. XM_039104898.2 → XP_038960826.1  kelch repeat and BTB domain-containing protein 4 isoform X4

      Conserved Domains (3) summary
      PHA03098
      Location:116 → 308
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:108 → 143
      Kelch; KELCH repeat [structural motif]
      cl28903
      Location:26 → 58
      BACK; BACK (BTB and C-terminal Kelch) domain

    4. XM_017591715.3 → XP_017447204.1  kelch repeat and BTB domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K102
      Related
      ENSRNOP00000071649.2, ENSRNOT00000084833.3
      Conserved Domains (4) summary
      PHA03098
      Location:82 → 514
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:314 → 349
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:48 → 187
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:177 → 264
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107746.1: Suppressed sequence

      Description
      NM_001107746.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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