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    Sil1 SIL1 nucleotide exchange factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sil1provided by RGD
    Official Full Name
    SIL1 nucleotide exchange factorprovided by RGD
    Primary source
    RGD:735103
    See related
    EnsemblRapid:ENSRNOG00000019826 AllianceGenome:RGD:735103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 100.2), Testes (RPKM 98.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sil1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27146526..27378459, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26872423..27104365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28067476..28302008, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 77 Neighboring gene catenin alpha 1 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC102550858 Neighboring gene uncharacterized LOC120098220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Zhao L, et al. Nat Genet, 2005 Sep. PMID 16116427
    2. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. Chung KT, et al. J Biol Chem, 2002 Dec 6. PMID 12356756
    3. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72590

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleotide exchange factor SIL1
    Names
    SIL1 homolog, endoplasmic reticulum chaperone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199376.1 → NP_955408.1  nucleotide exchange factor SIL1 precursor

      See identical proteins and their annotated locations for NP_955408.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062050
      UniProtKB/Swiss-Prot
      Q6P6S4
      UniProtKB/TrEMBL
      A0A8I6ANJ4, A6J2X3
      Conserved Domains (1) summary
      pfam08609
      Location:197 → 226
      Fes1; Nucleotide exchange factor Fes1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27146526..27378459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772025.4 → XP_008770247.1  nucleotide exchange factor SIL1 isoform X1

      See identical proteins and their annotated locations for XP_008770247.1

      UniProtKB/Swiss-Prot
      Q6P6S4
      UniProtKB/TrEMBL
      A0A8I6ANJ4, A6J2X3
      Conserved Domains (1) summary
      pfam08609
      Location:197 → 226
      Fes1; Nucleotide exchange factor Fes1

    2. XM_017600905.3 → XP_017456394.1  nucleotide exchange factor SIL1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6S4
      UniProtKB/TrEMBL
      A0A8I6ANJ4, A6J2X3
      Related
      ENSRNOP00000097662.1, ENSRNOT00000102716.2
      Conserved Domains (1) summary
      pfam08609
      Location:197 → 226
      Fes1; Nucleotide exchange factor Fes1

    3. XM_039096718.2 → XP_038952646.1  nucleotide exchange factor SIL1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6S4
      UniProtKB/TrEMBL
      A0A8I6ANJ4, A6J2X3

    4. XM_039096720.2 → XP_038952648.1  nucleotide exchange factor SIL1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSQ7
      Related
      ENSRNOP00000078831.1, ENSRNOT00000104681.2

    5. XM_039096722.2 → XP_038952650.1  nucleotide exchange factor SIL1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6S4.1 GenPept UniProtKB/Swiss-Prot:Q6P6S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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