Rab11fip1 RAB11 family interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab11fip1provided by RGD
Official Full Name: RAB11 family interacting protein 1provided by RGD
Primary source: RGD:1562965
See related: EnsemblRapid:ENSRNOG00000058940 AllianceGenome:RGD:1562965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562965; Rab11-FIP1
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of adiponectin secretion and regulated exocytosis. Predicted to be located in cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 112.8), Kidney (RPKM 46.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71589753..71620341)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (64886902..64917491)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (69048739..69079332)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An interaction with Rab11 is necessary for long-range targeting of beta1 integrins to the growth cone along axons and in neurons.
Title: Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI290060 (e-PCR)
- UniSTS:243968

d16rat58 (e-PCR)
- UniSTS:121158

d16rat59 (e-PCR)
- UniSTS:121159

RH140285 (e-PCR)
- UniSTS:222363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of adiponectin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 1

Names: RAB11 family interacting protein 1 (class I); rab-coupling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191555.1 → NP_001178484.1 rab11 family-interacting protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC107469, JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2JYK2

Related

ENSRNOP00000070687.1, ENSRNOT00000078128.3

Conserved Domains (2) summary

cd08682
Location:20 → 150

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:1132 → 1179

RBD-FIP; FIP domain
NM_001197241.1 → NP_001184170.1 rab11 family-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001184170.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC107469, JAXUCZ010000016

UniProtKB/Swiss-Prot

Q3B7T9

Related

ENSRNOP00000073557.1, ENSRNOT00000086082.4

Conserved Domains (2) summary

cd08682
Location:20 → 150

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:591 → 638

RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

71589753..71620341

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094778.2 → XP_038950706.1 rab11 family-interacting protein 1 isoform X1

Conserved Domains (3) summary

PTZ00449
Location:272 → 610

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03307
Location:606 → 931

PHA03307; transcriptional regulator ICP4; Provisional

pfam09457
Location:981 → 1028

RBD-FIP; FIP domain