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    Fbxw2 F-box and WD repeat domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxw2provided by RGD
    Official Full Name
    F-box and WD repeat domain containing 2provided by RGD
    Primary source
    RGD:1310460
    See related
    EnsemblRapid:ENSRNOG00000018687 AllianceGenome:RGD:1310460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytoplasm. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 156.3), Thymus (RPKM 147.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxw2 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38486358..38511683, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18088859..18114387, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13871513..13897033, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 5 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene proteasome 26S subunit, non-ATPase 5 Neighboring gene cutA divalent cation tolerance homolog-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Maruyama S, et al. Genomics, 2001 Dec. PMID 11735228
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 2
    Names
    F-box and WD-40 domain protein 2
    F-box and WD-40 domain-containing protein 2
    protein MD6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107835.2 → NP_001101305.1  F-box/WD repeat-containing protein 2

      See identical proteins and their annotated locations for NP_001101305.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166990
      UniProtKB/Swiss-Prot
      B2RZ17
      UniProtKB/TrEMBL
      A0A8L2QDA1
      Related
      ENSRNOP00000025399.5, ENSRNOT00000025399.6
      Conserved Domains (3) summary
      smart00256
      Location:60 → 94
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151 → 185
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:140 → 447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      38486358..38511683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591849.3 → XP_017447338.1  F-box/WD repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QDA1
      Conserved Domains (3) summary
      smart00256
      Location:87 → 121
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:178 → 212
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:167 → 442
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006233976.3 → XP_006234038.1  F-box/WD repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABP5, A0A8L2QDA1
      Related
      ENSRNOP00000090377.1, ENSRNOT00000109847.2
      Conserved Domains (3) summary
      smart00256
      Location:87 → 121
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:178 → 212
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:167 → 474
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RZ17.1 GenPept UniProtKB/Swiss-Prot:B2RZ17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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