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    Ikzf2 IKAROS family zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ikzf2provided by RGD
    Official Full Name
    IKAROS family zinc finger 2provided by RGD
    Primary source
    RGD:1308686
    See related
    EnsemblRapid:ENSRNOG00000027430 AllianceGenome:RGD:1308686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfpn1a2
    Summary
    Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 241.3), Muscle (RPKM 48.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ikzf2 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (78495670..78640896, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (71046038..71191296, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (76621230..76771017, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094697 Neighboring gene PC-esterase domain containing 1B like 1 Neighboring gene uncharacterized LOC134480292 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sperm associated antigen 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Clinical significance of expanded Foxp3⁺ Helios⁻ regulatory T cells in patients with non-small cell lung cancer. Muto S, et al. Int J Oncol, 2015 Dec. PMID 26460798, Free PMC Article
    2. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Kelley CM, et al. Curr Biol, 1998 Apr 23. PMID 9560339
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Helios
    Names
    zinc finger protein, subfamily 1A, 2 (Helios)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106916.2 → NP_001100386.2  zinc finger protein Helios

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KFF3
      Related
      ENSRNOP00000101201.1, ENSRNOT00000160705.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      78495670..78640896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245120.5 → XP_006245182.1  zinc finger protein Helios isoform X4

      See identical proteins and their annotated locations for XP_006245182.1

      UniProtKB/TrEMBL
      A6KFF3
      Conserved Domains (3) summary
      COG5048
      Location:138 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063266957.1 → XP_063123027.1  zinc finger protein Helios isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGQ5, A6KFF3

    3. XM_063266955.1 → XP_063123025.1  zinc finger protein Helios isoform X1

      UniProtKB/TrEMBL
      A6KFF3

    4. XM_008767219.4 → XP_008765441.1  zinc finger protein Helios isoform X6

      UniProtKB/TrEMBL
      A6KFF3
      Related
      ENSRNOP00000109346.1, ENSRNOT00000155133.1
      Conserved Domains (4) summary
      COG5048
      Location:122 → 196
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:131 → 151
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:129 → 151
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:143 → 168
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063266959.1 → XP_063123029.1  zinc finger protein Helios isoform X5

      UniProtKB/TrEMBL
      A6KFF3

    6. XM_063266961.1 → XP_063123031.1  zinc finger protein Helios isoform X7

      UniProtKB/TrEMBL
      A6KFF3

    7. XM_063266954.1 → XP_063123024.1  zinc finger protein Helios isoform X1

      UniProtKB/TrEMBL
      A6KFF3

    8. XM_006245119.5 → XP_006245181.1  zinc finger protein Helios isoform X4

      See identical proteins and their annotated locations for XP_006245181.1

      UniProtKB/TrEMBL
      A6KFF3
      Conserved Domains (3) summary
      COG5048
      Location:138 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    9. XM_063266956.1 → XP_063123026.1  zinc finger protein Helios isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGQ5, A6KFF3
      Related
      ENSRNOP00000111682.1, ENSRNOT00000121577.1

    10. XM_039083325.2 → XP_038939253.1  zinc finger protein Helios isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMW5, A6KFF3
      Conserved Domains (3) summary
      COG5048
      Location:144 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:160 → 185
      zf-H2C2_2; Zinc-finger double domain

    11. XM_063266958.1 → XP_063123028.1  zinc finger protein Helios isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGQ5, A6KFF3

    12. XM_006245121.5 → XP_006245183.1  zinc finger protein Helios isoform X4

      See identical proteins and their annotated locations for XP_006245183.1

      UniProtKB/TrEMBL
      A6KFF3
      Conserved Domains (3) summary
      COG5048
      Location:138 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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