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    Fras1 Fraser extracellular matrix complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289486, updated on 9-Dec-2024

    Summary

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    Symbol
    Fras1provided by RGD
    Full Name
    Fraser extracellular matrix complex subunit 1provided by RGD
    Primary source
    RGD:1306516
    See related
    EnsemblRapid:ENSRNOG00000002053 AllianceGenome:RGD:1306516
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 130.6), Lung (RPKM 66.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fras1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    74
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (13095370..13506895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12791407..13200862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14438392..14853016, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481719 Neighboring gene U2 spliceosomal RNA Neighboring gene annexin A3 Neighboring gene uncharacterized LOC134481720 Neighboring gene uncharacterized LOC103693729 Neighboring gene uncharacterized LOC120096573 Neighboring gene mitochondrial ribosomal protein L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Wang F, et al. Hum Mol Genet, 2013 Sep 15. PMID 23669348
    2. Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. McGregor L, et al. Nat Genet, 2003 Jun. PMID 12766769
    3. Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. Caruana G, et al. PLoS One, 2013. PMID 23469164, Free PMC Article
    4. Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Jadeja S, et al. Nat Genet, 2005 May. PMID 15838507
    5. Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. Chiotaki R, et al. Gene Expr Patterns, 2007 Feb. PMID 17251066

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    extracellular matrix organizing protein FRAS1
    Names
    Fraser syndrome 1
    extracellular matrix protein FRAS1
    extracellular matrix protein FRAS1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415086.2 → NP_001402015.1  extracellular matrix organizing protein FRAS1 precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AIZ0, F1M3H3
      Related
      ENSRNOP00000093123.1, ENSRNOT00000100214.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      13095370..13506895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091669.2 → XP_038947597.1  extracellular matrix organizing protein FRAS1 isoform X1

      UniProtKB/TrEMBL
      F1M3H3
      Conserved Domains (8) summary
      pfam03302
      Location:405 → 780
      VSP; Giardia variant-specific surface protein
      smart00214
      Location:27 → 86
      VWC; von Willebrand factor (vWF) type C domain
      smart00261
      Location:1045 → 1086
      FU; Furin-like repeats
      TIGR00845
      Location:2781 → 3048
      caca; sodium/calcium exchanger 1
      pfam00093
      Location:224 → 277
      VWC; von Willebrand factor type C domain
      cl17735
      Location:368 → 415
      VWC; von Willebrand factor type C domain
      pfam16184
      Location:2296 → 2407
      Cadherin_3; Cadherin-like
      cl02522
      Location:2554 → 2651
      Calx-beta; Calx-beta domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191595.1: Suppressed sequence

      Description
      NM_001191595.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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