Parp2 poly (ADP-ribose) polymerase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp2provided by RGD
Official Full Name: poly (ADP-ribose) polymerase 2provided by RGD
Primary source: RGD:1310568
See related: EnsemblRapid:ENSRNOG00000008892 AllianceGenome:RGD:1310568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adprtl2
Summary: Predicted to enable several functions, including NAD+-protein ADP-ribosyltransferase activity; poly-ADP-D-ribose binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Involved in hippocampal neuron apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; and response to oxygen-glucose deprivation. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus and site of DNA damage. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 91.8), Spleen (RPKM 88.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26494722..26517893)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24034069..24044340)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (27739416..27749650)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.
Title: PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.
MiR-125 might attenuate RA development by regulating PI3K/Akt/mTOR signaling pathway via directly inhibiting PARP2 expression.
Title: miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2.
Results provide evidence for a new role for PARP2 as a lipid-modulated regulator of lipid metabolism.
Title: Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis.
ALA attenuated cardiac hypertrophy, at least partially via inhibition of PARP-2 and subsequent activation of SIRT1.
Title: Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.
These findings shed new light on the understanding of PARP-2-related cardiomyopathy.
Title: PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1.
Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Title: Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD DNA ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-serine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in response to oxygen-glucose deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase 2

Names: ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; poly (ADP-ribose) polymerase family, member 2

NP_001099500.1

EC 2.4.2.30

XP_006251918.1

EC 2.4.2.30

XP_038949031.1

EC 2.4.2.30

XP_038949032.1

EC 2.4.2.30

XP_063130167.1

EC 2.4.2.30

XP_063130168.1

EC 2.4.2.30

XP_063130169.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106030.1 → NP_001099500.1 poly [ADP-ribose] polymerase 2

See identical proteins and their annotated locations for NP_001099500.1

Status: PROVISIONAL

Source sequence(s)

CH474040

UniProtKB/TrEMBL

A6KEA9, G3V749

Conserved Domains (3) summary

cd08003
Location:85 → 187

WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases

cd01437
Location:206 → 551

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:340 → 552

PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

26494722..26517893

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274097.1 → XP_063130167.1 poly [ADP-ribose] polymerase 2 isoform X1

UniProtKB/TrEMBL

A6KEA9, G3V749

Related

ENSRNOP00000099105.1, ENSRNOT00000123945.1
XM_063274099.1 → XP_063130169.1 poly [ADP-ribose] polymerase 2 isoform X4
XM_063274098.1 → XP_063130168.1 poly [ADP-ribose] polymerase 2 isoform X2
XM_039093103.2 → XP_038949031.1 poly [ADP-ribose] polymerase 2 isoform X3

Related

ENSRNOP00000011840.6, ENSRNOT00000011840.8

Conserved Domains (1) summary

PLN03124
Location:19 → 537

PLN03124; poly [ADP-ribose] polymerase; Provisional
XM_006251856.5 → XP_006251918.1 poly [ADP-ribose] polymerase 2 isoform X5

Conserved Domains (3) summary

cd08003
Location:1 → 91

WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases

cd01437
Location:110 → 455

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:244 → 456

PARP; Poly(ADP-ribose) polymerase catalytic domain
XM_039093104.2 → XP_038949032.1 poly [ADP-ribose] polymerase 2 isoform X6

Conserved Domains (1) summary

cd01437
Location:25 → 370

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...