Aldh1a3 aldehyde dehydrogenase 1 family, member A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh1a3provided by RGD
Official Full Name: aldehyde dehydrogenase 1 family, member A3provided by RGD
Primary source: RGD:628662
See related: EnsemblRapid:ENSRNOG00000052070 AllianceGenome:RGD:628662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aldh6
Summary: Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in several processes, including kidney development; pituitary gland development; and retinoic acid biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 138.6), Lung (RPKM 99.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (129392516..129436552, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (119982272..120017416, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (127302920..127337828, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study is the first to show that RALDH2 and RALDH3, but not RALDH1, are expressed in the embryonic anterior pituitary gland of the rat.
Title: Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC283541P1 (e-PCR)
- UniSTS:272407

RH136871 (e-PCR)
- UniSTS:218960

AA848809 (e-PCR)
- UniSTS:260978

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thyroid hormone binding	IEA Inferred from Electronic Annotation more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Harderian gland development	IEA Inferred from Electronic Annotation more info
involved_in Harderian gland development	ISO Inferred from Sequence Orthology more info
involved_in aldehyde metabolic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in face development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within face development	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in nose development	ISO Inferred from Sequence Orthology more info
involved_in nucleus accumbens development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleus accumbens development	ISO Inferred from Sequence Orthology more info
involved_in olfactory pit development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within olfactory pit development	ISO Inferred from Sequence Orthology more info
involved_in optic cup morphogenesis involved in camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in retinoic acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in righting reflex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinaldehyde dehydrogenase 3

Names: RALDH-3; aldehyde dehydrogenase 6; aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1, subfamily A3; ralDH3

NP_695212.2

EC 1.2.1.36

XP_038958335.1

EC 1.2.1.36

XP_038958341.1

EC 1.2.1.36

XP_063138470.1

EC 1.2.1.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153300.2 → NP_695212.2 retinaldehyde dehydrogenase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2JUS6, A0A9K3Y6M8, A9EEP5, B2GUU8

Related

ENSRNOP00000069212.2, ENSRNOT00000085158.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

129392516..129436552 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282400.1 → XP_063138470.1 retinaldehyde dehydrogenase 3 isoform X2
XM_039102407.2 → XP_038958335.1 retinaldehyde dehydrogenase 3 isoform X1

UniProtKB/Swiss-Prot

Q8K4D8

UniProtKB/TrEMBL

A0A8I6A4D2, A9EEP5

Related

ENSRNOP00000087440.1, ENSRNOT00000098068.2

Conserved Domains (1) summary

cd07141
Location:33 → 471

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
XM_039102413.2 → XP_038958341.1 retinaldehyde dehydrogenase 3 isoform X2

Conserved Domains (1) summary

cl11961
Location:1 → 387

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily