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    Fastkd3 FAST kinase domains 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fastkd3provided by RGD
    Official Full Name
    FAST kinase domains 3provided by RGD
    Primary source
    RGD:1309729
    See related
    EnsemblRapid:ENSRNOG00000027422 AllianceGenome:RGD:1309729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309729
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing; mitochondrial cytochrome c oxidase assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTKD3 (FAST kinase domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 59.6), Kidney (RPKM 56.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fastkd3 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36686727..36695376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34858342..34866988, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37734400..37742932, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 2 Neighboring gene RNA, U6 small nuclear 783 Neighboring gene cilia and flagella associated protein 90 Neighboring gene uncharacterized LOC134482589 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. Boehm E, et al. J Biol Chem, 2016 Dec 9. PMID 27789713, Free PMC Article
    2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082574.1 → NP_001076043.1  FAST kinase domain-containing protein 3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001076043.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079475, CK359441
      UniProtKB/Swiss-Prot
      Q68FN9
      UniProtKB/TrEMBL
      A6JV27
      Related
      ENSRNOP00000029498.4, ENSRNOT00000034410.8
      Conserved Domains (3) summary
      smart00952
      Location:589 → 646
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:405 → 473
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:489 → 575
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      36686727..36695376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227811.3 → XP_006227873.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006227873.1

      UniProtKB/Swiss-Prot
      Q68FN9
      UniProtKB/TrEMBL
      A6JV27
      Conserved Domains (3) summary
      smart00952
      Location:589 → 646
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:405 → 473
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:489 → 575
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_006227809.4 → XP_006227871.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006227871.1

      UniProtKB/Swiss-Prot
      Q68FN9
      UniProtKB/TrEMBL
      A6JV27
      Conserved Domains (3) summary
      smart00952
      Location:589 → 646
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:405 → 473
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:489 → 575
      FAST_2; FAST kinase-like protein, subdomain 2

    3. XM_039102861.2 → XP_038958789.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6JV28
      Conserved Domains (2) summary
      smart00952
      Location:120 → 177
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam08368
      Location:18 → 106
      FAST_2; FAST kinase-like protein, subdomain 2

    4. XM_063282704.1 → XP_063138774.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZW50

    RNA

    1. XR_010063812.1 RNA Sequence

      Related
      ENSRNOT00000079186.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FN9.2 GenPept UniProtKB/Swiss-Prot:Q68FN9

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