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    Dock11 dedicator of cytokinesis 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313438, updated on 9-Dec-2024

    Summary

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    Symbol
    Dock11provided by RGD
    Full Name
    dedicator of cytokinesis 11provided by RGD
    Primary source
    RGD:1564707
    See related
    EnsemblRapid:ENSRNOG00000013321 AllianceGenome:RGD:1564707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 243.3), Thymus (RPKM 237.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock11 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (119997523..120180643)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (115131720..115314854)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (122507169..122690463)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 13 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene uncharacterized LOC134484095 Neighboring gene interleukin 13 receptor subunit alpha 1 Neighboring gene zinc finger CCHC-type containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Matsuda T, et al. Immun Ageing, 2015. PMID 25729399, Free PMC Article
    2. Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Sakabe I, et al. Immun Ageing, 2012 Apr 11. PMID 22494997, Free PMC Article
    3. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. Nishikimi A, et al. FEBS Lett, 2005 Feb 14. PMID 15710388
    4. The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Jaudon F, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851601, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in marginal zone B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191760.2 → NP_001178689.1  dedicator of cytokinesis protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZSP2, F1LQ91
      Related
      ENSRNOP00000032402.5, ENSRNOT00000032275.8
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1615 → 2027
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:161 → 284
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:166 → 271
      PH; PH domain
      pfam11878
      Location:54 → 145
      DUF3398; Domain of unknown function (DUF3398)

    2. NM_001434047.1 → NP_001420976.1  dedicator of cytokinesis protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JV16, A0A8I6ANI1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      119997523..120180643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602037.3 → XP_017457526.1  dedicator of cytokinesis protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSP2
      Related
      ENSRNOP00000108069.1, ENSRNOT00000128569.1

    2. XM_006257453.5 → XP_006257515.1  dedicator of cytokinesis protein 11 isoform X1

      Related
      ENSRNOP00000069314.1, ENSRNOT00000080517.3
      Conserved Domains (5) summary
      cd08697
      Location:639 → 828
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11700
      Location:1628 → 2040
      DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
      cd13267
      Location:161 → 284
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:166 → 271
      PH; PH domain
      pfam11878
      Location:54 → 145
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein Strain
    Heading Accession and Version

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