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    Mybl1 MYB proto-oncogene like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mybl1provided by RGD
    Official Full Name
    MYB proto-oncogene like 1provided by RGD
    Primary source
    RGD:1306940
    See related
    EnsemblRapid:ENSRNOG00000021669 AllianceGenome:RGD:1306940
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including male meiosis I; positive regulation of DNA-templated transcription; and spermatogenesis. Predicted to act upstream of with a positive effect on siRNA-mediated retrotransposon silencing by heterochromatin formation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 58.5), Kidney (RPKM 34.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mybl1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14365768..14401012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9582905..9618179)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9279756..9315112)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene valosin containing protein interacting protein 1 Neighboring gene vexin Neighboring gene alcohol dehydrogenase, iron containing, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A-MYB (MYBL1) transcription factor is a master regulator of male meiosis. Bolcun-Filas E, et al. Development, 2011 Aug. PMID 21750041, Free PMC Article
    2. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Li XZ, et al. Mol Cell, 2013 Apr 11. PMID 23523368, Free PMC Article
    3. DNA binding and transactivation activity of A-myb, a c-myb-related gene. Ma XP, et al. Cancer Res, 1994 Dec 15. PMID 7987850
    4. The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Zhang D, et al. Development, 2018 May 30. PMID 29848638
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of piRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myb-related protein A
    Names
    myeloblastosis oncogene-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106632.1 → NP_001100102.1  myb-related protein A

      See identical proteins and their annotated locations for NP_001100102.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      A0A8I6AI21, A6JFG1
      Related
      ENSRNOP00000099403.1, ENSRNOT00000132216.1
      Conserved Domains (4) summary
      smart00717
      Location:87 → 135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87 → 133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:240 → 283
      LMSTEN; LMSTEN motif
      pfam09316
      Location:483 → 644
      Cmyb_C; C-myb, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14365768..14401012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237749.5 → XP_006237811.1  myb-related protein A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AI21, A0A8I6ARW4
      Related
      ENSRNOP00000094567.1, ENSRNOT00000099850.2
      Conserved Domains (4) summary
      smart00717
      Location:87 → 135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87 → 133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242 → 285
      LMSTEN; LMSTEN motif
      pfam09316
      Location:485 → 646
      Cmyb_C; C-myb, C-terminal

    2. XM_006237752.5 → XP_006237814.1  myb-related protein A isoform X4

      UniProtKB/TrEMBL
      A0A8I6AI21, D3ZF01
      Related
      ENSRNOP00000062710.3, ENSRNOT00000067977.4
      Conserved Domains (4) summary
      smart00717
      Location:87 → 135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87 → 133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242 → 285
      LMSTEN; LMSTEN motif
      pfam09316
      Location:485 → 646
      Cmyb_C; C-myb, C-terminal

    3. XM_039109395.2 → XP_038965323.1  myb-related protein A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AI21
      Conserved Domains (4) summary
      PLN03091
      Location:107 → 215
      PLN03091; hypothetical protein; Provisional
      pfam13921
      Location:61 → 121
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam07988
      Location:265 → 308
      LMSTEN; LMSTEN motif
      pfam09316
      Location:508 → 667
      Cmyb_C; C-myb, C-terminal

    4. XM_039109393.2 → XP_038965321.1  myb-related protein A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI21
      Related
      ENSRNOP00000092705.2, ENSRNOT00000099708.2
      Conserved Domains (4) summary
      PLN03091
      Location:107 → 215
      PLN03091; hypothetical protein; Provisional
      pfam13921
      Location:61 → 121
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam07988
      Location:265 → 308
      LMSTEN; LMSTEN motif
      pfam09316
      Location:508 → 667
      Cmyb_C; C-myb, C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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