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Zfp36 zinc finger protein 36 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79426, updated on 9-Dec-2024

Summary

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Official Symbol: Zfp36provided by RGD
Official Full Name: zinc finger protein 36provided by RGD
Primary source: RGD:620722
See related: EnsemblRapid:ENSRNOG00000058388 AllianceGenome:RGD:620722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tis11
Summary: Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of cell differentiation; negative regulation of inflammatory response; and regulation of RNA metabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Predicted to be part of CCR4-NOT complex and ribonucleoprotein complex. Orthologous to human ZFP36 (ZFP36 ring finger protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 86.9), Spleen (RPKM 86.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Zfp36 in Genome Data Viewer

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (92796628..92799108, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (83669084..83671564, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (85380088..85382565)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-beta as a novel mRNA stability regulator in intestinal epithelium through its ability to promote TTP expression and subsequent P-body formation.
Title: Transforming growth factor β regulates P-body formation through induction of the mRNA decay factor tristetraprolin.
These findings indicate a role for TTP in the insulin-mediated activation of hepatic HMGR transcription.
Title: Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin.
recruitment of TIS11 to heat shock-induced stress granules is governed by the tandem zinc finger domains of this protein
Title: Recruitment of mRNA-destabilizing protein TIS11 to stress granules is mediated by its zinc finger domain.
Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11
Title: Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Bda11 (e-PCR)
- UniSTS:239758

Zfp36 (e-PCR), detects polymorphism
- UniSTS:144828

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR AU-rich region binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within RNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA-mediated gene silencing by inhibition of translation	IEA Inferred from Electronic Annotation more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of polynucleotide adenylyltransferase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of polynucleotide adenylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular mRNA localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IEA Inferred from Electronic Annotation more info
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
NOT part_of exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
NOT part_of exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mRNA decay activator protein ZFP36

Names: TPA-induced sequence 11; TTP; tristetraprolin; tristetraproline; zfp-36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.