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    H2ax H2A.X variant histone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500987, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2axprovided by RGD
    Official Full Name
    H2A.X variant histoneprovided by RGD
    Primary source
    RGD:1566119
    See related
    EnsemblRapid:ENSRNOG00000074924 AllianceGenome:RGD:1566119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    H2afx; RGD1566119
    Summary
    Predicted to enable several functions, including chromatin-protein adaptor activity; damaged DNA binding activity; and histone binding activity. Predicted to be a structural constituent of chromatin. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus and site of double-strand break. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See H2ax in Genome Data Viewer
    Location:
    8q22
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53568718..53570072)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44671907..44673262)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48665652..48666981)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene C2CD2-like Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11 core subunit of CORVET and HOPS complexes

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity  
    enables damaged DNA binding  
    enables enzyme binding  
    enables histone binding  
    enables protein heterodimerization activity  
    enables structural constituent of chromatin  
    Component Evidence Code Pubs
    located_in XY body  
    located_in centrosome  
    located_in chromatin  
    located_in chromosome  
    located_in chromosome, telomeric region  
    located_in condensed nuclear chromosome  
    located_in male germ cell nucleus  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    part_of nucleosome  
    is_active_in nucleus  
    located_in nucleus  
    located_in replication fork  
    located_in site of DNA damage  
    is_active_in site of double-strand break  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    H2A.X variant histone
    Names
    H2A histone family, member X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109291.3NP_001102761.1  H2A.X variant histone

      See identical proteins and their annotated locations for NP_001102761.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2QY15, A6J3X1, D3ZXP3
      Related
      ENSRNOP00000103194.1, ENSRNOT00000128521.1
      Conserved Domains (1) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53568718..53570072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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